RT Journal Article
T1 Loss of Bone Mineral Density Associated with Age in Male Rats Fed on Sunflower Oil Is Avoided by Virgin Olive Oil Intake or Coenzyme Q Supplementation
A1 Varela-Lopez, Alfonso
A1 Ochoa, Julio J.
A1 Llamas-Elvira, Jose M.
A1 Lopez-Frias, Magdalena
A1 Planells, Elena
A1 Speranza, Lorenza
A1 Battino, Maurizio
A1 Quiles, Jose L.
K1 bone mineral density
K1 F-2-isoprostanes
K1 oxidative stress
K1 MUFA
K1 PUFA
K1 Oxidative stress
K1 Osteoclast differentiation
K1 Clinical epidemiology
K1 Eicosapentaenoic acid
K1 Antioxidant capacity
K1 Hip fracture
K1 Older-adults
K1 Fatty-acids
K1 Osteoporosis
K1 Women
AB The role of dietary fat unsaturation and the supplementation of coenzyme Q have been evaluated in relation to bone health. Male Wistar rats were maintained for 6 or 24 months on two diets varying in the fat source, namely virgin olive oil, rich in monounsaturated fatty acids, or sunflower oil, rich in n-6 polyunsaturated fatty acids. Both dietary fats were supplemented or not with coenzyme Q(10) (CoQ(10)). Bone mineral density (BMD) was evaluated in the femur. Serum levels of osteocalcin, osteopontin, receptor activator of nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG), adrenocorticotropin (ACTH) and parathyroid hormone (PTH), as well as urinary F-2-isoprostanes were measured. Aged animals fed on virgin olive oil showed higher BMD than those fed on sunflower oil. In addition, CoQ(10) prevented the age-related decline in BMD in animals fed on sunflower oil. Urinary F-2-isoprostanes analysis showed that sunflower oil led to the highest oxidative status in old animals, which was avoided by supplementation with CoQ(10). In conclusion, lifelong feeding on virgin olive oil or the supplementation of sunflower oil on CoQ(10) prevented, at least in part mediated by a low oxidative stress status, the age-related decrease in BMD found in sunflower oil fed animals.
PB Mdpi
YR 2017
FD 2017-07-01
LK http://hdl.handle.net/10668/19281
UL http://hdl.handle.net/10668/19281
LA en
DS RISalud
RD Apr 5, 2025