RT Journal Article
T1 Glucagon-like peptide 1 and Glucagon-like peptide 2 in relation to osteoporosis in non-diabetic postmenopausal women.
A1 Montes Castillo, María Cristina
A1 Martínez Ramírez, María José
A1 Soriano Arroyo, Rubén
A1 Prieto Gomez, Isabel
A1 Segarra Robles, Ana Belén
A1 Garrido-Martínez, Macarena
A1 Santiago-Fernández, Piedad
A1 Delgado Rodríguez, Miguel
AB Osteoporosis results from an imbalance in bone remodeling, which is known to follow a circadian rhythm determined by a functional relationship between intestine and bone tissue. Specific intestinal peptides have been identified as mediators. Glucagon-like peptide 1 and glucagon-like peptide 2, have been associated with bone health. Our main objective was to determine whether postprandial plasma levels of glucagon-like peptide 1, glucagon-like peptide 2 and dipeptidyl-peptidase 4 activity, are associated with osteoporosis in non-diabetic postmenopausal women. We studied non-diabetic postmenopausal women with osteoporosis diagnosed by dual-energy X-ray absorptiometry (cases, n = 43) and age-matched (±1 yr) controls without osteoporosis or a history of osteoporotic fracture (n = 43). We measured postprandial plasma levels of glucagon-like peptide 1, glucagon-like peptide 2, and dipeptidyl-peptidase 4 activity, bone mineral density, and baseline levels of bone remodeling markers and analyzed the food intake using a food-frequency questionnaire. Postprandial glucagon-like peptide 1 values were lower (p 
YR 2019
FD 2019-09-20
LK http://hdl.handle.net/10668/14526
UL http://hdl.handle.net/10668/14526
LA en
DS RISalud
RD Apr 7, 2025