RT Journal Article
T1 Development and Validation of a Clinical-Genetic Risk Score to Predict Hepatic Encephalopathy in Patients With Liver Cirrhosis.
A1 Gil-Gómez, Antonio
A1 Ampuero, Javier
A1 Rojas, Ángela
A1 Gallego-Durán, Rocío
A1 Muñoz-Hernández, Rocío
A1 Rico, María C
A1 Millán, Raquel
A1 García-Lozano, Raúl
A1 Francés, Rubén
A1 Soriano, Germán
A1 Romero-Gómez, Manuel
AB We aimed to define the impact of the genetic background on overt hepatic encephalopathy (HE) in patients with liver cirrhosis by developing a combined clinical-genetic risk score. Patients suffering from liver cirrhosis from the outpatient clinics of 4 hospitals (n = 600) were included and followed up for at least 5 years until HE bouts, liver transplant, or death. Patients were genotyped for 60 candidate single nucleotide polymorphisms together with the microsatellite in the promoter region of the gene GLS. Single nucleotide polymorphisms rs601338 (FUT2), rs5743836 (TRL9), rs2562582 (SLC1A3), rs313853 (SLC1A5), and GLS microsatellite did predict independently the incidence and severity of overt HE and were included as genetic score. Competing risk analysis revealed that bilirubin (subhazard ratio [sHR] 1.30 [1.15-1.48], P  The genetic background influenced overt HE risk and severity. The clinical-genetic HE Risk score, which combined genetic background together with albumin, bilirubin, and previous episodes of overt HE, could be a useful tool to predict overt HE in patients with cirrhosis.
YR 2021
FD 2021
LK http://hdl.handle.net/10668/17573
UL http://hdl.handle.net/10668/17573
LA en
DS RISalud
RD Apr 9, 2025