RT Journal Article T1 Impact of COVID-19 on the Health of the General and More Vulnerable Population and Its Determinants: Health Care and Social Survey-ESSOC, Study Protocol. A1 Sánchez-Cantalejo, Carmen A1 Rueda, María Del Mar A1 Saez, Marc A1 Enrique, Iria A1 Ferri, Ramón A1 Fuente, Miguel de La A1 Villegas, Román A1 Castro, Luis A1 Barceló, Maria Antònia A1 Daponte-Codina, Antonio A1 Lorusso, Nicola A1 Cabrera-León, Andrés K1 COVID-19 K1 SARS-CoV-2 K1 health determinants K1 health inequalities K1 machine learning K1 population registries K1 public health K1 real-world data K1 surveys K1 vulnerable populations AB This manuscript describes the rationale and protocol of a real-world data (RWD) study entitled Health Care and Social Survey (ESSOC, Encuesta Sanitaria y Social). The study's objective is to determine the magnitude, characteristics, and evolution of the COVID-19 impact on overall health as well as the socioeconomic, psychosocial, behavioural, occupational, environmental, and clinical determinants of both the general and more vulnerable population. The study integrates observational data collected through a survey using a probabilistic, overlapping panel design, and data from clinical, epidemiological, demographic, and environmental registries. The data will be analysed using advanced statistical, sampling, and machine learning techniques. The study is based on several measurements obtained from three random samples of the Andalusian (Spain) population: general population aged 16 years and over, residents in disadvantaged areas, and people over the age of 55. Given the current characteristics of this pandemic and its future repercussions, this project will generate relevant information on a regular basis, commencing from the beginning of the State of Alarm. It will also establish institutional alliances of great social value, explore and apply powerful and novel methodologies, and produce large, integrated, high-quality and open-access databases. The information described here will be vital for health systems in order to design tailor-made interventions aimed at improving the health care, health, and quality of life of the populations most affected by the COVID-19 pandemic. YR 2021 FD 2021-07-31 LK http://hdl.handle.net/10668/18321 UL http://hdl.handle.net/10668/18321 LA en DS RISalud RD Apr 6, 2025