RT Journal Article
T1 Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study.
A1 Carmona-Segovia, Ada-Del-Mar
A1 Doncel-Abad, Maria Victoria
A1 Becerra-Muñoz, Victor M
A1 Rodriguez-Capitan, Jorge
A1 Sabatel-Perez, Fernando
A1 Flores-Lopez, Maria
A1 Sanchez-Quintero, Maria Jose
A1 Medina-Vera, Dina
A1 Molina-Ramos, Ana Isabel
A1 El-Bekay, Rajaa
A1 Morales-Asencio, Jose Miguel
A1 Angullo-Gomez, Maria
A1 Garcia-Rodriguez, Luis
A1 Palma-Marti, Lucia
A1 Pavon-Moron, Francisco Javier
A1 Jimenez-Navarro, Manuel F
K1 Adult cardiology
K1 Coronary intervention
K1 Geriatric medicine
K1 Ischaemic heart disease
K1 Myocardial infarction
AB The incidence of acute coronary syndrome is rising in step with the growth of life expectancy. An increase in the age of patients with coronary artery disease has been related to in-hospital mortality, which has seen an upsurge over a short period of time. However, there is no consensus about the percutaneous coronary angioplasty strategy to follow for older patients with multivessel coronary artery disease (MVCAD). Complete revascularisation (CR) or incomplete revascularisation (ICR) strategy depends on prognosis but this has not yet been accurately described because of geriatric conditions and comorbidities. The aim of this study is to evaluate changes of clinical and biochemical parameters in older patients with MVCAD undergoing revascularisation and to establish a prognostic stratification model for CR and ICR. This observational, longitudinal, prospective study will include 150 patients with MVCAD and subsequent revascularisation who attend the Hospital Universitario Virgen de la Victoria (Málaga, Spain). Because of the dropout rates, 180 patients will be recruited at the beginning. Sociodemographic characteristics, clinical and angiographic parameters, and biochemical variables, such as cardiovascular, metabolic, inflammatory, stress oxidative biomarkers, will be collected in the admission for coronary revascularisation and three follow-ups at 6, 12 and 18 months. Statistical analyses will be conducted with these data using CR and ICR as the primary exposure variable. Relevant explanatory variables will be selected from a predictive model for their inclusion in a prognostic stratification model. The primary outcome measures will be major adverse cardiovascular events. Protocols and patient information have been approved by the regional research ethics committee (CEIm Provincial de Málaga-PEIBA (PI0131/2020). The results will be disseminated in international peer-reviewed journals, presented at conferences in Cardiology and Gerontology, and sent to participants, medical and health service managers, clinicians and other researchers.
PB BMJ Group
YR 2022
FD 2022-02-28
LK http://hdl.handle.net/10668/20142
UL http://hdl.handle.net/10668/20142
LA en
NO Carmona-Segovia ADM, Doncel-Abad MV, Becerra-Muñoz VM, Rodríguez-Capitán J, Sabatel-Pérez F, Flores-López M, et al. Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study. BMJ Open. 2022 Feb 28;12(2):e058042
DS RISalud
RD May 10, 2025