RT Journal Article
T1 Protective Effects of Melatonin on the Skin: Future Perspectives.
A1 Rusanova, Iryna
A1 Martínez-Ruiz, Laura
A1 Florido, Javier
A1 Rodríguez-Santana, César
A1 Guerra-Librero, Ana
A1 Acuña-Castroviejo, Darío
A1 Escames, Germaine
K1 aging
K1 melatonin
K1 mitochondria
K1 oxidative stress
K1 skin
AB When exposed to hostile environments such as radiation, physical injuries, chemicals, pollution, and microorganisms, the skin requires protective chemical molecules and pathways. Melatonin, a highly conserved ancient molecule, plays a crucial role in the maintenance of skin. As human skin has functional melatonin receptors and also acts as a complete system that is capable of producing and regulating melatonin synthesis, melatonin is a promising candidate for its maintenance and protection. Below, we review the studies of new metabolic pathways involved in the protective functions of melatonin in dermal cells. We also discuss the advantages of the topical use of melatonin for therapeutic purposes and skin protection. In our view, endogenous intracutaneous melatonin production, together with topically-applied exogenous melatonin and its metabolites, represent two of the most potent defense systems against external damage to the skin.
YR 2019
FD 2019-10-08
LK http://hdl.handle.net/10668/14722
UL http://hdl.handle.net/10668/14722
LA en
DS RISalud
RD Apr 18, 2025