TY - JOUR AU - Bellapart, Judith AU - Roberts, Jason Alexander AU - Appadurai, Vinesh AU - Wallis, Steven C AU - Nuñez-Nuñez, Maria AU - Boots, Robert James PY - 2016 DO - 10.1515/cclm-2015-0323 UR - http://hdl.handle.net/10668/10194 T2 - Clinical chemistry and laboratory medicine AB - Loss of circadian rhythms and reduced concentrations of endogenous melatonin are common in critically ill patients. After exogenous administration, supra-physiological concentrations in serum are only ephemeral, which may explain the absence of... LA - en KW - Administration, Oral KW - Adult KW - Aged KW - Central Nervous System Depressants KW - Critical Illness KW - Humans KW - Melatonin KW - Middle Aged TI - Pharmacokinetics of a novel dosing regimen of oral melatonin in critically ill patients. TY - research article VL - 54 ER -