RT Journal Article
T1 Impact of nitric oxide in liver cancer microenvironment.
A1 Dios-Barbeito, Sandra
A1 González, Raúl
A1 Cadenas, Miryam
A1 García, Lisander F
A1 Victor, Victor M
A1 Padillo, Francisco J
A1 Muntané, Jordi
K1 Cancer stem cells
K1 Hepatocarcinoma
K1 Hepatocellular carcinoma
K1 Nitric oxide synthase
K1 Tumor-associated fibroblasts
K1 Tumor-associated macrophages
AB The pro- or antitumoral properties of nitric oxide (NO) are dependent on local concentration, redox state, cellular status, duration of exposure and compartmentalization of NO generation. The intricate network of the tumor microenvironment (TME) is constituted by tumor cells, stromal and immune cells surrounded by active components of extracellular matrix that influence the biological behavior and, consequently, the treatment and prognosis of cancer. The review describes critical events in the crosstalk of cellular and stromal components in the TME, with special emphasis in the impact of NO generation in the regulation of hepatocellular carcinoma (HCC). The increased expression of nitric oxide synthase (NOS) in tumors and NO-end products in plasma have been associated with poor prognosis of cancer. We have assessed the level of the different isoforms of NOS in tumors and its relation to cell proliferation and death markers, and cell death receptor expression in tumors, and apoptotic markers and ligands of TNF-α receptor family in blood from a cohort of patients with HCC from different etiologies submitted to orthotopic liver transplantation (OLT). The high levels of NOS2 in tumors were associated with low plasma concentration of apoptotic markers (M30 and M65), FasL and TNF-α in HCV patients. By contrast, the low levels of NOS2 in tumors from alcohol-derived patients was associated with increased Trail-R1 expression in tumors, and circulating Trail levels compared to observed in plasma from HCV- and alcohol + HCV-derived patients. This study reinforces the association between increased NOS2 expression and potential risk of low patients' survival in HCC. However, a differential functional relevance of NOS expression in HCC seems to be influenced by etiologies.
YR 2022
FD 2022-08-05
LK http://hdl.handle.net/10668/22425
UL http://hdl.handle.net/10668/22425
LA en
DS RISalud
RD Apr 18, 2025