RT Journal Article
T1 Do nutrients and other bioactive molecules from foods have anything to say in the treatment against COVID-19?
A1 Quiles, José L
A1 Rivas-García, Lorenzo
A1 Varela-López, Alfonso
A1 Llopis, Juan
A1 Battino, Maurizio
A1 Sánchez-González, Cristina
K1 Curcumin
K1 Polyphenols
K1 Vitamin C
K1 Vitamin D
K1 Zinc
AB The repositioning of therapeutic agents already approved by the regulatory agencies for the use of drugs is very interesting due to the immediacy of their use; similarly, the possibility of using molecules derived from foods, whether nutrients or not, is of great importance, also because of their immediate therapeutic applicability. Candidates for these natural therapies against COVID-19 should show certain effects, such as restoring mitochondrial function and cellular redox balance. This would allow reducing the susceptibility of risk groups and the cascade of events after SARS-CoV-2 infection, responsible for the clinical picture, triggered by the imbalance towards oxidation, inflammation, and cytokine storm. Possible strategies to follow through the use of substances of food origin would include: a) the promotion of mitophagy to remove dysfunctional mitochondria originating from free radicals, proton imbalance and virus evasion of the immune system; b) the administration of transition metals whose redox activity would lead to their own oxidation and the consequent generation of a reduced environment, which would normalize the oxidative state and the intracellular pH; c) the administration of molecules with demonstrated antioxidant capacity; d) the administration of compounds with anti-inflammatory and vasodilatory activity; e) the administration of immunomodulatory compounds.
YR 2020
FD 2020-08-22
LK http://hdl.handle.net/10668/16142
UL http://hdl.handle.net/10668/16142
LA en
DS RISalud
RD Apr 7, 2025