RT Journal Article
T1 The genetic architecture of the human cerebral cortex.
A1 Grasby, Katrina L
A1 Jahanshad, Neda
A1 Painter, Jodie N
A1 Colodro-Conde, Lucía
A1 Bralten, Janita
A1 Hibar, Derrek P
A1 Lind, Penelope A
A1 Pizzagalli, Fabrizio
A1 Ching, Christopher R K
A1 McMahon, Mary Agnes B
A1 Shatokhina, Natalia
A1 Zsembik, Leo C P
A1 Thomopoulos, Sophia I
A1 Zhu, Alyssa H
A1 Strike, Lachlan T
A1 Agartz, Ingrid
A1 Alhusaini, Saud
A1 Almeida, Marcio A A
A1 Alnæs, Dag
A1 Amlien, Inge K
A1 Andersson, Micael
A1 Ard, Tyler
A1 Armstrong, Nicola J
A1 Ashley-Koch, Allison
A1 Atkins, Joshua R
A1 Bernard, Manon
A1 Brouwer, Rachel M
A1 Buimer, Elizabeth E L
A1 Bülow, Robin
A1 Bürger, Christian
A1 Cannon, Dara M
A1 Chakravarty, Mallar
A1 Chen, Qiang
A1 Cheung, Joshua W
A1 Couvy-Duchesne, Baptiste
A1 Dale, Anders M
A1 Dalvie, Shareefa
A1 de Araujo, Tânia K
A1 de Zubicaray, Greig I
A1 de Zwarte, Sonja M C
A1 den Braber, Anouk
A1 Doan, Nhat Trung
A1 Dohm, Katharina
A1 Ehrlich, Stefan
A1 Engelbrecht, Hannah-Ruth
A1 Erk, Susanne
A1 Fan, Chun Chieh
A1 Fedko, Iryna O
A1 Foley, Sonya F
A1 Ford, Judith M
A1 Fukunaga, Masaki
A1 Garrett, Melanie E
A1 Ge, Tian
A1 Giddaluru, Sudheer
A1 Goldman, Aaron L
A1 Green, Melissa J
A1 Groenewold, Nynke A
A1 Grotegerd, Dominik
A1 Gurholt, Tiril P
A1 Gutman, Boris A
A1 Hansell, Narelle K
A1 Harris, Mathew A
A1 Harrison, Marc B
A1 Haswell, Courtney C
A1 Hauser, Michael
A1 Herms, Stefan
A1 Heslenfeld, Dirk J
A1 Ho, New Fei
A1 Hoehn, David
A1 Hoffmann, Per
A1 Holleran, Laurena
A1 Hoogman, Martine
A1 Hottenga, Jouke-Jan
A1 Ikeda, Masashi
A1 Janowitz, Deborah
A1 Jansen, Iris E
A1 Jia, Tianye
A1 Jockwitz, Christiane
A1 Kanai, Ryota
A1 Karama, Sherif
A1 Kasperaviciute, Dalia
A1 Kaufmann, Tobias
A1 Kelly, Sinead
A1 Kikuchi, Masataka
A1 Klein, Marieke
A1 Knapp, Michael
A1 Knodt, Annchen R
A1 Krämer, Bernd
A1 Lam, Max
A1 Lancaster, Thomas M
A1 Lee, Phil H
A1 Lett, Tristram A
A1 Lewis, Lindsay B
A1 Lopes-Cendes, Iscia
A1 Luciano, Michelle
A1 Macciardi, Fabio
A1 Marquand, Andre F
A1 Mathias, Samuel R
A1 Melzer, Tracy R
A1 Milaneschi, Yuri
A1 Mirza-Schreiber, Nazanin
A1 Moreira, Jose C V
A1 Mühleisen, Thomas W
A1 Müller-Myhsok, Bertram
A1 Najt, Pablo
A1 Nakahara, Soichiro
A1 Nho, Kwangsik
A1 Olde Loohuis, Loes M
A1 Orfanos, Dimitri Papadopoulos
A1 Pearson, John F
A1 Pitcher, Toni L
A1 Pütz, Benno
A1 Quidé, Yann
A1 Ragothaman, Anjanibhargavi
A1 Rashid, Faisal M
A1 Reay, William R
A1 Redlich, Ronny
A1 Reinbold, Céline S
A1 Repple, Jonathan
A1 Richard, Geneviève
A1 Riedel, Brandalyn C
A1 Risacher, Shannon L
A1 Rocha, Cristiane S
A1 Mota, Nina Roth
A1 Salminen, Lauren
A1 Saremi, Arvin
A1 Saykin, Andrew J
A1 Schlag, Fenja
A1 Schmaal, Lianne
A1 Schofield, Peter R
A1 Secolin, Rodrigo
A1 Shapland, Chin Yang
A1 Shen, Li
A1 Shin, Jean
A1 Shumskaya, Elena
A1 Sønderby, Ida E
A1 Sprooten, Emma
A1 Tansey, Katherine E
A1 Teumer, Alexander
A1 Thalamuthu, Anbupalam
A1 Tordesillas-Gutiérrez, Diana
A1 Turner, Jessica A
A1 Uhlmann, Anne
A1 Vallerga, Costanza Ludovica
A1 van der Meer, Dennis
A1 van Donkelaar, Marjolein M J
A1 van Eijk, Liza
A1 van Erp, Theo G M
A1 van Haren, Neeltje E M
A1 van Rooij, Daan
A1 van Tol, Marie-José
A1 Veldink, Jan H
A1 Verhoef, Ellen
A1 Walton, Esther
A1 Wang, Mingyuan
A1 Wang, Yunpeng
A1 Wardlaw, Joanna M
A1 Wen, Wei
A1 Westlye, Lars T
A1 Whelan, Christopher D
A1 Witt, Stephanie H
A1 Wittfeld, Katharina
A1 Wolf, Christiane
A1 Wolfers, Thomas
A1 Wu, Jing Qin
A1 Yasuda, Clarissa L
A1 Zaremba, Dario
A1 Zhang, Zuo
A1 Zwiers, Marcel P
A1 Artiges, Eric
A1 Assareh, Amelia A
A1 Ayesa-Arriola, Rosa
A1 Belger, Aysenil
A1 Brandt, Christine L
A1 Brown, Gregory G
A1 Cichon, Sven
A1 Curran, Joanne E
A1 Davies, Gareth E
A1 Degenhardt, Franziska
A1 Dennis, Michelle F
A1 Dietsche, Bruno
A1 Djurovic, Srdjan
A1 Doherty, Colin P
A1 Espiritu, Ryan
A1 Garijo, Daniel
A1 Gil, Yolanda
A1 Gowland, Penny A
A1 Green, Robert C
A1 Häusler, Alexander N
A1 Heindel, Walter
A1 Ho, Beng-Choon
A1 Hoffmann, Wolfgang U
A1 Holsboer, Florian
A1 Homuth, Georg
A1 Hosten, Norbert
A1 Jack, Clifford R
A1 Jang, MiHyun
A1 Jansen, Andreas
A1 Kimbrel, Nathan A
A1 Kolskår, Knut
A1 Koops, Sanne
A1 Krug, Axel
A1 Lim, Kelvin O
A1 Luykx, Jurjen J
A1 Mathalon, Daniel H
A1 Mather, Karen A
A1 Mattay, Venkata S
A1 Matthews, Sarah
A1 Mayoral Van Son, Jaqueline
A1 McEwen, Sarah C
A1 Melle, Ingrid
A1 Morris, Derek W
A1 Mueller, Bryon A
A1 Nauck, Matthias
A1 Nordvik, Jan E
A1 Nöthen, Markus M
A1 O'Leary, Daniel S
A1 Opel, Nils
A1 Martinot, Marie-Laure Paillère
A1 Pike, G Bruce
A1 Preda, Adrian
A1 Quinlan, Erin B
A1 Rasser, Paul E
A1 Ratnakar, Varun
A1 Reppermund, Simone
A1 Steen, Vidar M
A1 Tooney, Paul A
A1 Torres, Fábio R
A1 Veltman, Dick J
A1 Voyvodic, James T
A1 Whelan, Robert
A1 White, Tonya
A1 Yamamori, Hidenaga
A1 Adams, Hieab H H
A1 Bis, Joshua C
A1 Debette, Stephanie
A1 Decarli, Charles
A1 Fornage, Myriam
A1 Gudnason, Vilmundur
A1 Hofer, Edith
A1 Ikram, M Arfan
A1 Launer, Lenore
A1 Longstreth, W T
A1 Lopez, Oscar L
A1 Mazoyer, Bernard
A1 Mosley, Thomas H
A1 Roshchupkin, Gennady V
A1 Satizabal, Claudia L
A1 Schmidt, Reinhold
A1 Seshadri, Sudha
A1 Yang, Qiong
A1 Alzheimer’s Disease Neuroimaging Initiative, 
A1 CHARGE Consortium, 
A1 EPIGEN Consortium, 
A1 IMAGEN Consortium, 
A1 SYS Consortium, 
A1 Parkinson’s Progression Markers Initiative, 
A1 Alvim, Marina K M
A1 Ames, David
A1 Anderson, Tim J
A1 Andreassen, Ole A
A1 Arias-Vasquez, Alejandro
A1 Bastin, Mark E
A1 Baune, Bernhard T
A1 Beckham, Jean C
A1 Blangero, John
A1 Boomsma, Dorret I
A1 Brodaty, Henry
A1 Brunner, Han G
A1 Buckner, Randy L
A1 Buitelaar, Jan K
A1 Bustillo, Juan R
A1 Cahn, Wiepke
A1 Cairns, Murray J
A1 Calhoun, Vince
A1 Carr, Vaughan J
A1 Caseras, Xavier
A1 Caspers, Svenja
A1 Cavalleri, Gianpiero L
A1 Cendes, Fernando
A1 Corvin, Aiden
A1 Crespo-Facorro, Benedicto
A1 Dalrymple-Alford, John C
A1 Dannlowski, Udo
A1 de Geus, Eco J C
A1 Deary, Ian J
A1 Delanty, Norman
A1 Depondt, Chantal
A1 Desrivières, Sylvane
A1 Donohoe, Gary
A1 Espeseth, Thomas
A1 Fernández, Guillén
A1 Fisher, Simon E
A1 Flor, Herta
A1 Forstner, Andreas J
A1 Francks, Clyde
A1 Franke, Barbara
A1 Glahn, David C
A1 Gollub, Randy L
A1 Grabe, Hans J
A1 Gruber, Oliver
A1 Håberg, Asta K
A1 Hariri, Ahmad R
A1 Hartman, Catharina A
A1 Hashimoto, Ryota
A1 Heinz, Andreas
A1 Henskens, Frans A
A1 Hillegers, Manon H J
A1 Hoekstra, Pieter J
A1 Holmes, Avram J
A1 Hong, L Elliot
A1 Hopkins, William D
A1 Hulshoff Pol, Hilleke E
A1 Jernigan, Terry L
A1 Jönsson, Erik G
A1 Kahn, René S
A1 Kennedy, Martin A
A1 Kircher, Tilo T J
A1 Kochunov, Peter
A1 Kwok, John B J
A1 Le Hellard, Stephanie
A1 Loughland, Carmel M
A1 Martin, Nicholas G
A1 Martinot, Jean-Luc
A1 McDonald, Colm
A1 McMahon, Katie L
A1 Meyer-Lindenberg, Andreas
A1 Michie, Patricia T
A1 Morey, Rajendra A
A1 Mowry, Bryan
A1 Nyberg, Lars
A1 Oosterlaan, Jaap
A1 Ophoff, Roel A
A1 Pantelis, Christos
A1 Paus, Tomas
A1 Pausova, Zdenka
A1 Penninx, Brenda W J H
A1 Polderman, Tinca J C
A1 Posthuma, Danielle
A1 Rietschel, Marcella
A1 Roffman, Joshua L
A1 Rowland, Laura M
A1 Sachdev, Perminder S
A1 Sämann, Philipp G
A1 Schall, Ulrich
A1 Schumann, Gunter
A1 Scott, Rodney J
A1 Sim, Kang
A1 Sisodiya, Sanjay M
A1 Smoller, Jordan W
A1 Sommer, Iris E
A1 St Pourcain, Beate
A1 Stein, Dan J
A1 Toga, Arthur W
A1 Trollor, Julian N
A1 Van der Wee, Nic J A
A1 van 't Ent, Dennis
A1 Völzke, Henry
A1 Walter, Henrik
A1 Weber, Bernd
A1 Weinberger, Daniel R
A1 Wright, Margaret J
A1 Zhou, Juan
A1 Stein, Jason L
A1 Thompson, Paul M
A1 Medland, Sarah E
A1 Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group, 
AB The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
YR 2020
FD 2020
LK https://hdl.handle.net/10668/27761
UL https://hdl.handle.net/10668/27761
LA en
DS RISalud
RD Apr 6, 2025