RT Journal Article
T1 Parental Prepuberty Overweight and Offspring Lung Function.
A1 Lønnebotn, Marianne
A1 Calciano, Lucia
A1 Johannessen, Ane
A1 Jarvis, Deborah L
A1 Abramson, Michael J
A1 Benediktsdóttir, Bryndís
A1 Bråbäck, Lennart
A1 Franklin, Karl A
A1 Godoy, Raúl
A1 Holm, Mathias
A1 Janson, Christer
A1 Jõgi, Nils O
A1 Kirkeleit, Jorunn
A1 Malinovschi, Andrei
A1 Pereira-Vega, Antonio
A1 Schlünssen, Vivi
A1 Dharmage, Shyamali C
A1 Accordini, Simone
A1 Gómez Real, Francisco
A1 Svanes, Cecilie
K1 ECRHS
K1 RHINE
K1 RHINESSA
K1 causal inference
K1 counterfactual-based mediation analysis
K1 father/paternal/male/men
K1 intergenerational
K1 lung function
K1 nutrition
K1 overweight
K1 prepuberty
AB In a recent study we found that fathers' but not mothers' onset of overweight in puberty was associated with asthma in adult offspring. The potential impact on offspring's adult lung function, a key marker of general and respiratory health, has not been studied. We investigated the potential causal effects of parents' overweight on adult offspring's lung function within the paternal and maternal lines. We included 929 offspring (aged 18-54, 54% daughters) of 308 fathers and 388 mothers (aged 40-66). Counterfactual-based multi-group mediation analyses by offspring's sex (potential moderator) were used, with offspring's prepubertal overweight and/or adult height as potential mediators. Unknown confounding was addressed by simulation analyses. Fathers' overweight before puberty had a negative indirect effect, mediated through sons' height, on sons' forced expiratory volume in one second (FEV1) (beta (95% CI): -144 (-272, -23) mL) and forced vital capacity (FVC) (beta (95% CI): -210 (-380, -34) mL), and a negative direct effect on sons' FVC (beta (95% CI): -262 (-501, -9) mL); statistically significant effects on FEV1/FVC were not observed. Mothers' overweight before puberty had neither direct nor indirect effects on offspring's lung function. Fathers' overweight starting before puberty appears to cause lower FEV1 and FVC in their future sons. The effects were partly mediated through sons' adult height but not through sons' prepubertal overweight.
YR 2022
FD 2022-04-04
LK http://hdl.handle.net/10668/21469
UL http://hdl.handle.net/10668/21469
LA en
DS RISalud
RD Apr 6, 2025