RT Journal Article
T1 Plasma microrna expression profile for reduced ejection fraction in dilated cardiomyopathy
A1 Calderon-Dominguez, Maria
A1 Belmonte, Thalía
A1 Quezada-Feijoo, Maribel
A1 Ramos, Mónica
A1 Calderon-Dominguez, Juan
A1 Campuzano, Oscar
A1 Mangas, Alipio
A1 Toro, Rocio
K1 Plasma
K1 Cardiomyopathy
K1 Heart diseases
K1 RNA
K1 MicroRNAs
K1 Cardiomiopatías
K1 Cardiopatías
K1 ARN
K1 MicroARNs
AB The left ventricular (LV) ejection fraction (EF) is key to prognosis in dilated cardiomyopathy (DCM). Circulating microRNAs have emerged as reliable biomarkers for heart diseases, included DCM. Clinicians need improved tools for greater clarification of DCM EF categorization, to identify high-risk patients. Thus, we investigated whether microRNA profiles can categorize DCM patients based on their EF. 179-differentially expressed circulating microRNAs were screened in two groups: (1) non-idiopathic DCM; (2) idiopathic DCM. Then, 26 microRNAs were identified and validated in the plasma of ischemic-DCM (n = 60), idiopathic-DCM (n = 55) and healthy individuals (n = 44). We identified fourteen microRNAs associated with echocardiographic variables that differentiated idiopathic DCM according to the EF degree. A predictive model of a three-microRNA (miR-130b-3p, miR-150-5p and miR-210-3p) combined with clinical variables (left bundle branch block, left ventricle end-systolic dimension, lower systolic blood pressure and smoking habit) was obtained for idiopathic DCM with a severely reduced-EF. The receiver operating characteristic curve analysis supported the discriminative potential of the diagnosis. Bioinformatics analysis revealed that miR-150-5p and miR-210-3p target genes might interact with each other with a high connectivity degree. In conclusion, our results revealed a three-microRNA signature combined with clinical variables that highly discriminate idiopathic DCM categorization. This is a potential novel prognostic biomarker with high clinical value.
PB Springer Nature
YR 2021
FD 2021-04-06
LK http://hdl.handle.net/10668/3816
UL http://hdl.handle.net/10668/3816
LA en
NO Calderon-Dominguez M, Belmonte T, Quezada-Feijoo M, Ramos M, Calderon-Dominguez J, Campuzano O, et al. Plasma microrna expression profile for reduced ejection fraction in dilated cardiomyopathy. Sci Rep. 2021 Apr 6;11(1):7517
DS RISalud
RD Apr 4, 2025