RT Journal Article
T1 Non-vitamin K antagonist oral anticoagulants and antiphospholipid syndrome.
A1 Sciascia, Savino
A1 Lopez-Pedrera, Chary
A1 Cecchi, Irene
A1 Pecoraro, Clara
A1 Roccatello, Dario
A1 Cuadrado, Maria Jose
K1 Anti-phospholipid antibodies
K1 Anti-phospholipid syndrome
K1 Apixaban
K1 Dabigatran
K1 Rivaroxaban
K1 Thrombosis
AB The current treatment of thrombotic APS patients includes long-term anticoagulation with oral vitamin K antagonists (VKAs), with warfarin being the one most commonly used. However, the use of VKAs can be challenging, especially in patients with APS. VKAs monitoring in patients with aPL is complicated by the heterogeneous responsiveness to LAs of reagents used in the International Normalized Ratio test, potentially resulting in instability of anticoagulation. For decades, VKAs were the only available oral anticoagulants. However, non-VKA oral anticoagulants, including a direct thrombin inhibitor (dabigatran etexilate) and direct anti-Xa inhibitors (rivaroxaban, apixaban and edoxaban), are currently available. The use of these agents may represent a major step forward since, unlike VKAs, they have few reported drug interactions and they do not interact with food or alcohol intake, thereby resulting in more stable anticoagulant intensity. Most importantly, monitoring their anticoagulant intensity is not routinely required due to their predictable anticoagulant effects. In this review, we discuss the clinical and laboratory aspects of non-VKA oral anticoagulants, focusing on the available evidence regarding their use in patients with APS.
PB Oxford University Press
YR 2015
FD 2015-12-21
LK http://hdl.handle.net/10668/9808
UL http://hdl.handle.net/10668/9808
LA en
NO Sciascia S, Lopez-Pedrera C, Cecchi I, Pecoraro C, Roccatello D, Cuadrado MJ. Non-vitamin K antagonist oral anticoagulants and antiphospholipid syndrome. Rheumatology (Oxford). 2016 Oct;55(10):1726-35
DS RISalud
RD Apr 7, 2025