RT Journal Article
T1 High First Trimester Levels of TSH as an Independent Risk Factor for Gestational Diabetes Mellitus: A Retrospective Cohort Study.
A1 Fernandez Alba, Juan Jesus
A1 Castillo Lara, Maria
A1 Jimenez Heras, Jose Manuel
A1 Moreno Cortes, Rocio
A1 Gonzalez Macias, Carmen
A1 Vilar Sanchez, Angel
A1 San Laureano, Florentino Carral
A1 Moreno Corral, Luis Javier
K1 Gestational diabetes mellitus
K1 Subclinical hyperthyroidism
K1 Subclinical hypothyroidism
K1 Thyroid antibodies
K1 Thyroid stimulating hormone
K1 Thyrotropin
AB Although numerous articles have found an association between alterations in thyroid function and the risk of gestational diabetes mellitus (GDM), other studies have failed to demonstrate this association. This may be due to the different cut-off points used to define subclinical hypothyroidism. We aim to clarify the role of thyroid stimulating hormone (TSH) level in GDM within pregnant women with normal free thyroxine (fT4) levels. This retrospective cohort study was performed in 6775 pregnant women. The association between TSH and GDM was assessed by bivariate and multivariate logistic regression. Pregnant women with subclinical hypothyroidism are at significantly greater risk for GDM when compared with euthyroid pregnant women (OR = 1.85; 95% CI = 1.36-2.52). We have also observed that TSH levels increase the risk of GDM within euthyroid pregnant women, since the TSH levels between 2.5 and 4.71 showed a higher risk of GDM than those whose TSH levels are between 0.31 and 2.49 (OR = 1.54; 95% CI = 1.28-1.84). In addition, pregnant women with positive thyroid antibodies have almost 2.5 times the risk of developing GDM (OR = 2.47; 95% CI = 1.57-3.89). Our results support that in pregnant women with normal fT4 levels, higher first trimester TSH level implies a higher risk of GDM.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-06-27
LK http://hdl.handle.net/10668/21311
UL http://hdl.handle.net/10668/21311
LA en
NO Fernández Alba JJ, Castillo Lara M, Jiménez Heras JM, Moreno Cortés R, González Macías C, Vilar Sánchez Á, et al. High First Trimester Levels of TSH as an Independent Risk Factor for Gestational Diabetes Mellitus: A Retrospective Cohort Study. J Clin Med. 2022 Jun 29;11(13):3776
DS RISalud
RD Apr 4, 2025