TY - JOUR AU - Márquez, Ana AU - Cénit, María Carmen AU - Cordero-Coma, Miguel AU - Ortego-Centeno, Norberto AU - Adán, Alfredo AU - Fonollosa, Alejandro AU - Díaz Valle, David AU - Pato, Esperanza AU - Blanco, Ricardo AU - Cañal, Joaquín AU - Díaz-Llopis, Manuel AU - Ramón, Enrique, de AU - Rio, María José, del AU - García Serrano, José Luis AU - Artaraz, Joseba AU - Martín-Villa, José Manuel AU - Llorenç, Víctor AU - Gorroño-Echebarría, Marina Begoña AU - Martín, Javier PY - 2013 DO - 10.1371/journal.pone.0076777 UR - http://hdl.handle.net/10668/1950 T2 - PloS one AB - OBJECTIVEInterferon (IFN) signaling plays a crucial role in autoimmunity. Genetic variation in interferon regulatory factor 5 (IRF5), a major regulator of the type I interferon induction, has been associated with risk of developing several autoimmune... LA - en PB - Public Library of Science KW - Factores reguladores del interferón KW - Uveítis anterior KW - Desequilibrio de ligamiento KW - Edema macular KW - Modelos logísticos KW - Fenotipo KW - Polimorfismo de nucleótido simple KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles KW - Medical Subject Headings::Check Tags::Female KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Gene Frequency KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Haplotypes KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::Interferon Regulatory Factors KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Linkage::Linkage Disequilibrium KW - Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Models, Statistical::Logistic Models KW - Medical Subject Headings::Diseases::Eye Diseases::Retinal Diseases::Retinal Degeneration::Macular Degeneration::Macular Edema KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide KW - Medical Subject Headings::Diseases::Eye Diseases::Uveal Diseases::Uveitis::Panuveitis::Uveitis, Anterior KW - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult TI - Two functional variants of IRF5 influence the development of macular edema in patients with non-anterior uveitis. TY - research article ER -