RT Journal Article
T1 Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma.
A1 Peinado, Paola
A1 Andrades, Alvaro
A1 Cuadros, Marta
A1 Rodriguez, Maria Isabel
A1 Coira, Isabel F
A1 Garcia, Daniel J
A1 Benitez-Cantos, Maria S
A1 Cano, Carlos
A1 Zarzuela, Eduardo
A1 Muñoz, Javier
A1 Loidi, Claudia
A1 Saiz, Monica
A1 Medina, Pedro P
K1 Epigenetics
K1 Lung adenocarcinoma
K1 Lung cancer
K1 Multi-omics
K1 Prognosis
K1 SWI/SNF complex
AB SWI/SNF complexes are major targets of mutations in cancer. Here, we combined multiple "-omics" methods to assess SWI/SNF composition and aberrations in LUAD. Mutations in lung SWI/SNF subunits were highly recurrent in our LUAD cohort (41.4%), and over 70% of the mutations were predicted to have functional impact. Furthermore, SWI/SNF expression in LUAD suffered an overall repression that could not be explained exclusively by genetic alterations. Finally, SWI/SNF mutations were associated with poorer overall survival in TCGA-LUAD. We propose SWI/SNF-mutant LUAD as a separate clinical subgroup with practical implications.
YR 2022
FD 2022-03-17
LK http://hdl.handle.net/10668/20358
UL http://hdl.handle.net/10668/20358
LA en
DS RISalud
RD Apr 18, 2025