%0 Journal Article
%A Peinado, Paola
%A Andrades, Alvaro
%A Cuadros, Marta
%A Rodriguez, Maria Isabel
%A Coira, Isabel F
%A Garcia, Daniel J
%A Benitez-Cantos, Maria S
%A Cano, Carlos
%A Zarzuela, Eduardo
%A Muñoz, Javier
%A Loidi, Claudia
%A Saiz, Monica
%A Medina, Pedro P
%T Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma.
%D 2022
%U http://hdl.handle.net/10668/20358
%X SWI/SNF complexes are major targets of mutations in cancer. Here, we combined multiple "-omics" methods to assess SWI/SNF composition and aberrations in LUAD. Mutations in lung SWI/SNF subunits were highly recurrent in our LUAD cohort (41.4%), and over 70% of the mutations were predicted to have functional impact. Furthermore, SWI/SNF expression in LUAD suffered an overall repression that could not be explained exclusively by genetic alterations. Finally, SWI/SNF mutations were associated with poorer overall survival in TCGA-LUAD. We propose SWI/SNF-mutant LUAD as a separate clinical subgroup with practical implications.
%K Epigenetics
%K Lung adenocarcinoma
%K Lung cancer
%K Multi-omics
%K Prognosis
%K SWI/SNF complex
%~