TY - JOUR AU - Rodríguez, Teresa AU - Méndez, Rosa AU - Campo, Ana Del AU - Jiménez, Pilar AU - Aptsiauri, Natalia AU - Garrido, Federico AU - Ruiz-Cabello, Francisco PY - 2007 DO - 10.1186/1471-2407-7-34 UR - http://hdl.handle.net/10668/616 T2 - BMC cancer AB - BACKGROUNDThe inability of cancer cells to present antigen on the cell surface via MHC class I molecules is one of the mechanisms by which tumor cells evade anti-tumor immunity. Alterations of Jak-STAT components of interferon (IFN)-mediated signaling... LA - en PB - BioMed Central KW - HLA Antigens KW - IRF1 protein, human KW - Interferon Regulatory Factor-1 KW - STAT1 Transcription Factor KW - STAT1 protein, human KW - Interferon-gamma KW - Interferón gamma KW - Melanoma KW - Fosforilación Oxidativa KW - Factor de Transcripción STAT1 KW - Transducción de Señal KW - Neoplasias Cutáneas KW - Activación Transcripcional KW - Células Tumorales Cultivadas KW - Antineoplastic Agents KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Major Histocompatibility Complex::Genes, MHC Class I KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::HLA Antigens KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::Interferon Regulatory Factors::Interferon Regulatory Factor-1 KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interferons::Interferon-gamma KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Nevi and Melanomas::Melanoma KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Phosphorylation KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::STAT Transcription Factors::STAT1 Transcription Factor KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Skin Neoplasms KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Transcriptional Activation KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents TI - Distinct mechanisms of loss of IFN-gamma mediated HLA class I inducibility in two melanoma cell lines TY - research article ER -