TY - JOUR AU - Geribaldi-Doldán, Noelia AU - Fernández-Ponce, Cecilia AU - Quiroz, Roberto Navarro AU - Sánchez-Gomar, Ismael AU - Escorcia, Lorena Gómez AU - Velásquez, Erika Puentes AU - Quiroz, Elkin Navarro PY - 2021 DO - 10.3389/fonc.2020.603495 UR - http://hdl.handle.net/10668/4021 T2 - Frontiers in Oncology AB - Glioblastoma (GB), the most aggressive malignant glioma, is made up of a large percentage of glioma-associated microglia/macrophages (GAM), suggesting that immune cells play an important role in the pathophysiology of GB. Under physiological... LA - en PB - Frontiers KW - Glioblastoma KW - Microglia KW - Signaling pathways KW - Therapeutic target KW - Epigenetic KW - Transducción de señal KW - Desarrollo de medicamentos KW - Epigenómica KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neoplasms, Neuroepithelial::Glioma::Astrocytoma::Glioblastoma KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Nerve Growth Factors::Glial Cell Line-Derived Neurotrophic Factors KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Cerebral Ventricles::Lateral Ventricles KW - Medical Subject Headings::Anatomy::Nervous System::Neuroglia::Microglia KW - Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease KW - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow KW - Medical Subject Headings::Anatomy::Cells::Stem Cells::Neural Stem Cells KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Signal Transduction KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic KW - Medical Subject Headings::Anatomy::Cells::Phagocytes::Macrophages TI - The Role of Microglia in Glioblastoma TY - review article ER -