RT Journal Article
T1 The Role of Microglia in Glioblastoma
A1 Geribaldi-Doldán, Noelia
A1 Fernández-Ponce, Cecilia
A1 Quiroz, Roberto Navarro
A1 Sánchez-Gomar, Ismael
A1 Escorcia, Lorena Gómez
A1 Velásquez, Erika Puentes
A1 Quiroz, Elkin Navarro
K1 Glioblastoma
K1 Microglia
K1 Signaling pathways
K1 Therapeutic target
K1 Epigenetic
K1 Transducción de señal
K1 Desarrollo de medicamentos
K1 Epigenómica
AB Glioblastoma (GB), the most aggressive malignant glioma, is made up of a large percentage of glioma-associated microglia/macrophages (GAM), suggesting that immune cells play an important role in the pathophysiology of GB. Under physiological conditions, microglia, the phagocytes of the central nervous system (CNS), are involved in various processes such as neurogenesis or axonal growth, and the progression of different conditions such as Alzheimer's disease. Through immunohistochemical studies, markers that enhance GB invasiveness have been shown to be expressed in the peritumoral area of ​​the brain, such as Transforming Growth Factor α (TGF-α), Stromal Sell-Derived Factor 1 (SDF1/CXCL12), Sphingosine-1-Phosphate (S1P) and Neurotrophic Factor Derived from the Glial cell line (GDNF), contributing to the increase in tumor mass. Similarly, it has also been described 17 biomarkers that are present in hypoxic periarteriolar HSC niches in bone marrow and in hypoxic periarteriolar GSC niches in glioblastoma. Interestingly, microglia plays an important role in the microenvironment that supports GB progression, being one of the most important focal points in the study of therapeutic targets for the development of new drugs. In this review, we describe the altered signaling pathways in microglia in the context of GB. We also show how microglia interact with glioblastoma cells and the epigenetic mechanisms involved. Regarding the interactions between microglia and neurogenic niches, some authors indicate that glioblastoma stem cells (GSC) are similar to neural stem cells (NSC), common stem cells in the subventricular zone (SVZ), suggesting that this could be the origin of GB. Understanding the similarities between SVZ and the tumor microenvironment could be important to clarify some mechanisms involved in GB malignancy and to support the discovering of new therapeutic targets for the development of more effective glioblastoma treatments.
PB Frontiers
YR 2021
FD 2021-01-29
LK http://hdl.handle.net/10668/4021
UL http://hdl.handle.net/10668/4021
LA en
NO Geribaldi-Doldán N, Fernández-Ponce C, Quiroz RN, Sánchez-Gomar I, Escorcia LG, Velásquez EP, et al. The Role of Microglia in Glioblastoma. Front Oncol. 2021 Jan 29;10:603495
DS RISalud
RD Apr 18, 2025