RT Journal Article
T1 Therapeutic alternatives in painful diabetic neuropathy: a meta-analysis of randomized controlled trials.
A1 Vilar, Samuel
A1 Castillo, Jose Manuel
A1 Munuera Martínez, Pedro V
A1 Reina, María
A1 Pabón, Manuel
K1 Chronic pain
K1 Diabetes complications
K1 Diabetic neuropathies
K1 Pain
K1 Pain management
K1 Pain unit
AB One of the most frequent problems caused by diabetes is the so called painful diabetic neuropathy. This condition can be treated through numerous types of therapy. The purpose of this study was to analyze, as a meta-analysis, different treatments used to alleviate painful diabetic neuropathy, with the aim of generating results that help making decisions when applying such treatments to tackle this pathology. A search was conducted in the main databases for Health Sciences, such as PUBMED, Web of Science (WOS), and IME biomedicina (Spanish Medical Reports in Biomedicine), to gather randomized controlled trials about treatments used for painful diabetic neuropathy. The analyzed studies were required to meet the inclusion criteria selected, especially those results related to pain intensity. Nine randomized controlled trials were chosen. The meta-analysis shows significant positive effects for those treatments based on tapentadol [g: -1.333, 95% CI (-1.594; -1.072), P  This meta-analysis indicates the effectiveness of the treatments based on duloxetine, gabapentin and pregabalin, as well as other drugs, such as tapentadol and topic clonidine, whose use is better prescribed in more specific situations. The results provided can help increase the knowledge about the treatment of painful diabetic neuropathy and also in the making of clinical practice guidelines for healthcare professionals.
SN 2005-9159
YR 2018
FD 2018-10-01
LK http://hdl.handle.net/10668/13067
UL http://hdl.handle.net/10668/13067
LA en
DS RISalud
RD Apr 7, 2025