RT Journal Article
T1 Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
A1 Stepien, Magdalena
A1 Jenab, Mazda
A1 Freisling, Heinz
A1 Becker, Niels-Peter
A1 Czuban, Magdalena
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Overvad, Kim
A1 Boutron-Ruault, Marie-Christine
A1 Mancini, Francesca Romana
A1 Savoye, Isabelle
A1 Katzke, Verena
A1 Kühn, Tilman
A1 Boeing, Heiner
A1 Iqbal, Khalid
A1 Trichopoulou, Antonia
A1 Bamia, Christina
A1 Orfanos, Philippos
A1 Palli, Domenico
A1 Sieri, Sabina
A1 Tumino, Rosario
A1 Naccarati, Alessio
A1 Panico, Salvatore
A1 Bueno-de-Mesquita, H B As
A1 Peeters, Petra H
A1 Weiderpass, Elisabete
A1 Merino, Susana
A1 Jakszyn, Paula
A1 Sanchez-Perez, Maria-Jose
A1 Dorronsoro, Miren
A1 Huerta, José María
A1 Barricarte, Aurelio
A1 Boden, Stina
A1 van Guelpen, Behany
A1 Wareham, Nick
A1 Khaw, Kay-Tee
A1 Bradbury, Kathryn E
A1 Cross, Amanda J
A1 Schomburg, Lutz
A1 Hughes, David J
AB Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to investigate the association between circulating levels of copper and zinc, and their calculated ratio, with risk of CRC development. Copper and zinc levels were measured by reflection X-ray fluorescence spectrometer in 966 cases and 966 matched controls. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression and are presented for the fifth versus first quintile. Higher circulating concentration of copper was associated with a raised CRC risk (OR = 1.50; 95% CI: 1.06, 2.13; P-trend = 0.02) whereas an inverse association with cancer risk was observed for higher zinc levels (OR = 0.65; 95% CI: 0.43, 0.97; P-trend = 0.07). Consequently, the ratio of copper/zinc was positively associated with CRC (OR = 1.70; 95% CI: 1.20, 2.40; P-trend = 0.0005). In subgroup analyses by follow-up time, the associations remained statistically significant only in those diagnosed within 2 years of blood collection. In conclusion, these data suggest that copper or copper levels in relation to zinc (copper to zinc ratio) become imbalanced in the process of CRC development. Mechanistic studies into the underlying mechanisms of regulation and action are required to further examine a possible role for higher copper and copper/zinc ratio levels in CRC development and progression.
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11263
UL http://hdl.handle.net/10668/11263
LA en
DS RISalud
RD Apr 7, 2025