%0 Journal Article
%A Alfonso, Fernando
%A Perez-Vizcayno, Maria Jose
%A del Blanco, Bruno Garcia
%A Garcia-Touchard, Arturo
%A Lopez-Minguez, Jose-Ramon
%A Masotti, Monica
%A Zueco, Javier
%A Melgares, Rafael
%A Mainar, Vicente
%A Moreno, Raul
%A Dominguez, Antonio
%A Sanchis, Juan
%A Bethencourt, Armando
%A Moreu, Jose
%A Cequier, Angel
%A Marti, Vicens
%A Otaegui, Imanol
%A Bastante, Teresa
%A Gonzalo, Nieves
%A Jimenez-Quevedo, Pilar
%A Cardenas, Alberto
%A Fernandez, Cristina
%A Spanish Soc Cardiology
%T Everolimus-Eluting Stents in Patients With Bare-Metal and Drug-Eluting In-Stent Restenosis Results From a Patient-Level Pooled Analysis of the RIBS IV and V Trials
%D 2016
%@ 1941-7640
%U http://hdl.handle.net/10668/19086
%X Background-Treatment of patients with drug-eluting stent (DES) in-stent restenosis (ISR) is more challenging than that of patients with bare-metal stent ISR. However, the results of everolimus-eluting stents (EES) in these distinct scenarios remain unsettled.Methods and Results-A pooled analysis of the RIBS IV (Restenosis Intra-Stent of Drug-Eluting Stents: Paclitaxel-Eluting Balloon vs Everolimus-Eluting Stent) and RIBS V (Restenosis Intra-Stent of Bare Metal Stents: Paclitaxel-Eluting Balloon vs Everolimus-Eluting Stent) randomized trials was performed using patient-level data to compare the efficacy of EES in bare-metal stent ISR and DES-ISR. Inclusion and exclusion criteria were identical in both trials. Results of 94 patients treated with EES for bare-metal stent ISR were compared with those of 155 patients treated with EES for DES-ISR. Baseline characteristics were more adverse in patients with DES-ISR, although they presented later and more frequently with a focal pattern. After intervention, minimal lumen diameter (2.22 +/- 0.5 versus 2.38 +/- 0.5 mm, P=0.01) was smaller in the DES-ISR group. Late angiographic findings (89.3% of eligible patients), including minimal lumen diameter (2.03 +/- 0.7 versus 2.36 +/- 0.6 mm, P
%K angiography
%K drug-eluting stents
%K everolimus
%K metal
%K regression analysis
%K restenosis
%K Coated balloon angioplasty
%K Efficacy
%K Neoatherosclerosis
%K Implantation
%K Multicenter
%K Outcomes
%K Safety
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