RT Journal Article T1 Comparative clinical outcomes for patients with advanced NSCLC harboring EGFR exon 20 insertion mutations and common EGFR mutations A1 Bazhenova, Lyudmila A1 Minchom, Anna A1 Viteri, Santiago A1 Bauml, Joshua M. A1 Ou, Sai-Hong Ignatius A1 Gadgeel, Shirish M. A1 Manuel Trigo, Jose A1 Backenroth, Daniel A1 Li, Tracy A1 Londhe, Anil A1 Mahadevia, Parthiv A1 Girard, Nicolas K1 Non-small cell lung cancer K1 Advanced lung cancer K1 EGFR mutations K1 EGFR exon 20 insertions K1 Flatiron registry K1 Cell lung-cancer K1 1st-line treatment K1 Open-label K1 Carboplatin-paclitaxel K1 Phase-iii K1 Chemotherapy K1 Afatinib K1 Adenocarcinoma K1 Gefitinib K1 Survival AB Introduction: Real-world clinical outcomes in patients with advanced NSCLC harboring EGFR exon 20 insertion (exon20ins) mutations have not been extensively studied. We conducted a retrospective cohort study to assess the clinical outcomes of EGFR exon20ins compared with common EGFR (cEGFR) mutations. Methods: Adults with advanced NSCLC harboring any EGFR mutations in the NSCLC Flatiron registry (2011 through May 2020) were included. To compare the relative prognosis (prognostic value) of exon20ins vs cEGFR, real-world overall survival (rwOS) was the primary endpoint. Separately, to compare the relative response to tyrosine kinase inhibitor (TKI) treatment (predictive value), real-world progression-free survival (rwPFS) was the primary endpoint. Results: For the prognostic value analysis, 3014 patients with EGFR mutant NSCLC (cEGFR, n = 2833; EGFR exon20ins, n = 181) were eligible. The median (95% CI) rwOS was 16.2 (11.04-19.38) months in the EGFR exon20ins cohort vs 25.5 (24.48-27.04) months in the cEGFR cohort (adjusted HR, 1.75 [1.45-2.131; p PB Elsevier ireland ltd SN 0169-5002 YR 2021 FD 2021-11-21 LK https://hdl.handle.net/10668/27958 UL https://hdl.handle.net/10668/27958 LA en DS RISalud RD Apr 12, 2025