RT Journal Article
T1 Global dissemination of a multidrug resistant Escherichia coli clone
A1 Petty, Nicola K
A1 Ben Zakour, Nouri L
A1 Stanton-Cook, Mitchell
A1 Skippington, Elizabeth
A1 Totsika, Makrina
A1 Forde, Brian M
A1 Phan, Minh-Duy
A1 Gomes Moriel, Danilo
A1 Peters, Kate M
A1 Davies, Mark
A1 Rogers, Benjamin A
A1 Dougan, Gordon
A1 Rodriguez-Baño, Jesús
A1 Pascual, Alvaro
A1 Pitout, Johann D D
A1 Upton, Mathew
A1 Paterson, David L
A1 Walsh, Timothy R
A1 Schembri, Mark A
A1 Beatson, Scott A
K1 Bacterial evolution
K1 Genomics
K1 Phylogeography
K1 Genomic epidemiology
K1 Secuencia de bases
K1 Farmacorresistencia bacteriana múltiple
K1 Escherichia coli
K1 Fluoroquinolonas
AB Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a high proportion of urinary tract and bloodstream infections. The rapid emergence and successful spread of E. coli ST131 is strongly associated with several factors, including resistance to fluoroquinolones, high virulence gene content, the possession of the type 1 fimbriae FimH30 allele, and the production of the CTX-M-15 extended spectrum β-lactamase (ESBL). Here, we used genome sequencing to examine the molecular epidemiology of a collection of E. coli ST131 strains isolated from six distinct geographical locations across the world spanning 2000-2011. The global phylogeny of E. coli ST131, determined from whole-genome sequence data, revealed a single lineage of E. coli ST131 distinct from other extraintestinal E. coli strains within the B2 phylogroup. Three closely related E. coli ST131 sublineages were identified, with little association to geographic origin. The majority of single-nucleotide variants associated with each of the sublineages were due to recombination in regions adjacent to mobile genetic elements (MGEs). The most prevalent sublineage of ST131 strains was characterized by fluoroquinolone resistance, and a distinct virulence factor and MGE profile. Four different variants of the CTX-M ESBL-resistance gene were identified in our ST131 strains, with acquisition of CTX-M-15 representing a defining feature of a discrete but geographically dispersed ST131 sublineage. This study confirms the global dispersal of a single E. coli ST131 clone and demonstrates the role of MGEs and recombination in the evolution of this important MDR pathogen.
PB National Academy of Sciences
SN 0027-8424
YR 2014
FD 2014-04-15
LK http://hdl.handle.net/10668/2614
UL http://hdl.handle.net/10668/2614
LA en
NO Petty NK, Ben Zakour NL, Stanton-Cook M, Skippington E, Totsika M, Forde BM, Phan MD, et al. Global dissemination of a multidrug resistant Escherichia coli clone. Proc Natl Acad Sci U S A. 2014;111(15):5694-9.
NO Australian National Health and Medical Research Council (NHMRC); the Australian Infectious Diseases Research Centre; ARC Discovery Early Career Researcher Award; Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, the Spanish Network for Research in Infectious Diseases; Fondo de Investigación Sanitaria and Junta de Andalucía.
DS RISalud
RD Apr 7, 2025