RT Journal Article
T1 Fundamental limit of detection of photonic biosensors with coherent phase read-out
A1 Molina-Fernández, Íñigo
A1 Leuermann, Jonas
A1 Ortega-Moñux, Alejandro
A1 Wangüemert-Pérez, J. Gonzalo
A1 Halir, Robert
K1 Técnicas biosensibles
K1 Límite de detección
K1 Interferometría
K1 Dispositivos ópticos
K1 Fotones
K1 Modelos teóricos
K1 Biosensing techniques
K1 Limit of detection
K1 Interferometry
K1 Optical devices
K1 Photons
K1 Models, theoretical
AB Photonic biosensors offer label-free detection of biomolecules for applications ranging from clinical diagnosis to food quality monitoring. Both sensors based on Mach-Zehnder interferometers and ring resonators are widely used, but are usually read-out using different schemes, making a direct comparison of their fundamental limit of detection challenging. A coherent detection scheme, adapted from optical communication systems, has been recently shown to achieve excellent detection limits, using a simple fixed-wavelength source. Here we present, for the first time, a theoretical model to determine the fundamental limit of detection of such a coherent read-out system, for both interferometric and resonant sensors. Based on this analysis, we provide guidelines for sensor optimization in the presence of optical losses and show that interferometric sensors are preferable over resonant structures when the sensor size is not limited by the available sample volume.
PB Optical Society of America
YR 2019
FD 2019-04-29
LK http://hdl.handle.net/10668/3373
UL http://hdl.handle.net/10668/3373
LA en
NO Molina-Fernández Í, Leuermann J, Ortega-Moñux A, Wangüemert-Pérez JG, Halir R. Fundamental limit of detection of photonic biosensors with coherent phase read-out. Opt Express. 2019 Apr 29;27(9):12616-12629.
DS RISalud
RD Apr 11, 2025