TY - JOUR AU - Götz, Marcus R AU - Collado, Juan A AU - Fernandez-Ruiz, Javier AU - Fiebich, Bernd L AU - Garcia-Toscano, Laura AU - Gomez-Cañas, Maria AU - Koch, Oskar AU - Leha, Andreas AU - Muñoz, Eduardo AU - Navarrete, Carmen AU - Pazos, Maria R AU - Holzgrabe, Ulrike PY - 2019 DO - 10.3389/fphar.2019.01284 SN - 1663-9812 UR - http://hdl.handle.net/10668/14812 T2 - Frontiers in pharmacology AB - Background: As a library of cannabinoid (CB) derivatives with (-)-trans-cannabidiol (CBD) or (-)-trans-cannabidivarin (CBDV) scaffold, we synthesized nine novel cannabinoids: 2-hydroxyethyl cannabidiolate (2-HEC), 2-hydroxypentyl cannabidiolate... LA - en PB - Frontiers Research Foundation KW - CB-receptor KW - CBD KW - CBDV KW - Agonist KW - Anti-inflammatory KW - Binding KW - Cannabidiol KW - Cannabidivarin KW - Cricetinae KW - Cytokines KW - Dinoprostone KW - Lipopolysaccharides KW - CHO Cells KW - Interleukin-6 KW - Complement Factor B KW - RNA, Messenger TI - Structure-Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives. TY - research article VL - 10 ER -