TY - JOUR AU - Villanueva-Paz, Marina AU - Niu, Hao AU - Segovia-Zafra, Antonio AU - Medina-Caliz, Inmaculada AU - Sanabria-Cabrera, Judith AU - Lucena, M. Isabel AU - Andrade, Raúl J. AU - Alvarez-Alvarez, Ismael PY - 2021 DO - 10.3390/jcm10225317 UR - http://hdl.handle.net/10668/3535 T2 - Journal of Clinical Medicine AB - Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifestations, which are sometimes severe (SCARs). Nevirapine,... LA - en PB - MDPI KW - Drug-induced liver injury KW - Severe cutaneous adverse reactions KW - Hypersensitivity KW - Gaps KW - Causality assessment KW - Diagnosis KW - Management KW - Clinical trial KW - Immune response KW - Enfermedad hepática inducida por sustancias y drogas KW - Hipersensibilidad KW - Relaciones intergeneracionales KW - Diagnóstico KW - Ensayo clínico KW - Inmunidad KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines::Allopurinol KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyridines::Nevirapine KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles KW - Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Granulation Tissue::Cicatrix KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class I::HLA-B Antigens KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Membrane Glycoproteins::Histocompatibility Antigens Class I::HLA-A Antigens KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis KW - Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Sulfonamides KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents KW - Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Pharmaceutical Preparations, Dental TI - Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions TY - review article ER -