RT Journal Article
T1 Impact of Nutrition on Pulmonary Arterial Hypertension
A1 Callejo, María
A1 Barberá, Joan Albert
A1 Duarte, Juan
A1 Perez-Vizcaino, Francisco
K1 Pulmonary hypertension
K1 Microbiota
K1 Vitamin C
K1 Vitamin D
K1 Iron
K1 Diet
K1 Hipertensión pulmonar
K1 Ácido ascórbico
K1 Vitamina D
K1 Hierro
K1 Dieta
AB Pulmonary arterial hypertension (PAH) is characterized by sustained vasoconstriction, vascular remodeling, inflammation, and in situ thrombosis. Although there have been important advances in the knowledge of the pathophysiology of PAH, it remains a debilitating, limiting, and rapidly progressive disease. Vitamin D and iron deficiency are worldwide health problems of pandemic proportions. Notably, these nutritional alterations are largely more prevalent in PAH patients than in the general population and there are several pieces of evidence suggesting that they may trigger or aggravate disease progression. There are also several case reports associating scurvy, due to severe vitamin C deficiency, with PAH. Flavonoids such as quercetin, isoflavonoids such as genistein, and other dietary polyphenols including resveratrol slow the progression of the disease in animal models of PAH. Finally, the role of the gut microbiota and its interplay with the diet, host immune system, and energy metabolism is emerging in multiple cardiovascular diseases. The alteration of the gut microbiota has also been reported in animal models of PAH. It is thus possible that in the near future interventions targeting the nutritional status and the gut dysbiosis will improve the outcome of these patients.
PB MDPI
YR 2020
FD 2020-01-07
LK http://hdl.handle.net/10668/3687
UL http://hdl.handle.net/10668/3687
LA en
NO Callejo M, Barberá JA, Duarte J, Perez-Vizcaino F. Impact of Nutrition on Pulmonary Arterial Hypertension. Nutrients. 2020 Jan 7;12(1):169
DS RISalud
RD Apr 11, 2025