RT Journal Article
T1 Progress and Hurdles of Therapeutic Nanosystems against Cancer.
A1 Martín-Contreras, Marina
A1 Navarro-Marchal, Saúl A
A1 Peula-García, José Manuel
A1 Jódar-Reyes, Ana Belén
K1 clinical application
K1 delivery
K1 design of nanosystems
K1 nanomedicine
K1 physicochemical properties
K1 protein corona
K1 targeting
AB Nanomedicine against cancer, including diagnosis, prevention and treatment, has increased expectations for the solution of many biomedical challenges in the fight against this disease. In recent decades, an exhaustive design of nanosystems with high specificity, sensitivity and selectivity has been achieved due to a rigorous control over their physicochemical properties and an understanding of the nano-bio interface. However, despite the considerable progress that has been reached in this field, there are still different hurdles that limit the clinical application of these nanosystems, which, along with their possible solutions, have been reviewed in this work. Specifically, physiological processes as biological barriers and protein corona formation related to the administration routes, designing strategies to overcome these obstacles, promising new multifunctional nanotherapeutics, and recent clinical trials are presented in this review.
SN 1999-4923
YR 2022
FD 2022-02-10
LK http://hdl.handle.net/10668/21543
UL http://hdl.handle.net/10668/21543
LA en
DS RISalud
RD Apr 11, 2025