RT Journal Article
T1 Previous Usutu Virus Exposure Partially Protects Magpies (Pica pica) against West Nile Virus Disease But Does Not Prevent Horizontal Transmission
A1 Escribano-Romero, Estela
A1 Jiménez de Oya, Nereida
A1 Camacho, María-Cruz
A1 Blázquez, Ana-Belén
A1 Martín-Acebes, Miguel A.
A1 Risalde, Maria A.
A1 Muriel, Laura
A1 Saiz, Juan-Carlos
A1 Höfle, Ursula
K1 Avian host
K1 Flaviviruses
K1 Co-infection
K1 Cross-protection
K1 Usutu virus
K1 West Nile virus
K1 Magpie
K1 Adaptación al huésped
K1 Coinfección
K1 Protección cruzada
AB The mosquito-borne flaviviruses USUV and WNV are known to co-circulate in large parts of Europe. Both are a public health concern, and USUV has been the cause of epizootics in both wild and domestic birds, and neurological cases in humans in Europe. Here, we explore the susceptibility of magpies to experimental USUV infection, and how previous exposure to USUV would affect infection with WNV. None of the magpies exposed to USUV showed clinical signs, viremia, or detectable neutralizing antibodies. After challenge with a neurovirulent WNV strain, neither viremia, viral titer of WNV in vascular feathers, nor neutralizing antibody titers of previously USUV-exposed magpies differed significantly with respect to magpies that had not previously been exposed to USUV. However, 75% (6/8) of the USUV-exposed birds survived, while only 22.2% (2/9) of those not previously exposed to USUV survived. WNV antigen labeling by immunohistochemistry in tissues was less evident and more restricted in magpies exposed to USUV prior to challenge with WNV. Our data indicate that previous exposure to USUV partially protects magpies against a lethal challenge with WNV, while it does not prevent viremia and direct transmission, although the mechanism is unclear. These results are relevant for flavivirus ecology and contention.
PB MDPI
YR 2021
FD 2021-07-20
LK http://hdl.handle.net/10668/3966
UL http://hdl.handle.net/10668/3966
LA en
NO Escribano-Romero E, Jiménez de Oya N, Camacho MC, Blázquez AB, Martín-Acebes MA, Risalde MA, et al. Previous Usutu Virus Exposure Partially Protects Magpies (Pica pica) against West Nile Virus Disease But Does Not Prevent Horizontal Transmission. Viruses. 2021 Jul 20;13(7):1409
DS RISalud
RD Apr 7, 2025