RT Journal Article
T1 Sex Differences in Infective Endocarditis After Transcatheter Aortic Valve Replacement.
A1 Panagides, Vassili
A1 Abdel-Wahab, Mohamed
A1 Mangner, Norman
A1 Durand, Eric
A1 Ihlemann, Nikolaj
A1 Urena, Marina
A1 Pellegrini, Costanza
A1 Giannini, Francesco
A1 Scislo, Piotr
A1 Huczek, Zenon
A1 Landt, Martin
A1 Auffret, Vincent
A1 Sinning, Jan Malte
A1 Cheema, Asim N
A1 Nombela-Franco, Luis
A1 Chamandi, Chekrallah
A1 Campelo-Parada, Francisco
A1 Munoz-Garcia, Erika
A1 Herrmann, Howard C
A1 Testa, Luca
A1 Kim, Won-Keun
A1 Eltchaninoff, Helene
A1 Sondergaard, Lars
A1 Himbert, Dominique
A1 Husser, Oliver
A1 Latib, Azeem
A1 le Breton, Hervé
A1 Servoz, Clement
A1 Gervais, Philippe
A1 Del Val, David
A1 Linke, Axel
A1 Crusius, Lisa
A1 Thiele, Holger
A1 Holzhey, David
A1 Rodés-Cabau, Josep
AB Outcomes after transcatheter aortic valve replacement (TAVR) and infectious diseases may vary according to sex. This multicentre study aimed to determine the sex differences in clinical characteristics, management, and outcomes of infective endocarditis (IE) after TAVR. A total of 579 patients (217 women, 37.5%) who had the diagnosis of definite IE following TAVR were included retrospectively from the Infectious Endocarditis After TAVR International Registry. Women were older (80 ± 8 vs 78 ± 8 years; P = 0.001) and exhibited a lower comorbidity burden. Clinical characteristics and microbiological profiles were similar between men and women, but culture-negative IE was more frequent in women (9.9% vs 4.3%; P = 0.009). A high proportion of patients had a clinical indication for surgery (54.4% in both groups; P = 0.99), but a surgical intervention was performed in a minority of patients (women 15.2%, men 20.3%; P = 0.13). The mortality rate at index IE hospitalisation was similar in both groups (women 35.4%, men 31.7%; P = 0.37), but women exhibited a higher mortality rate at 2-year follow-up (63% vs 52.1%; P = 0.021). Female sex remained an independent risk factor for cumulative mortality in the multivariable analysis (adjusted HR 1.28, 95% CI 1.02-1.62; P = 0.035). After adjustment for in-hospital events, surgery was not associated with better outcomes in women. There were no significant sex-related differences in the clinical characteristics and management of IE after TAVR. However, female sex was associated with increased 2-year mortality risk.
YR 2022
FD 2022-07-14
LK http://hdl.handle.net/10668/22102
UL http://hdl.handle.net/10668/22102
LA en
DS RISalud
RD Apr 7, 2025