RT Journal Article
T1 Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus
A1 Sánchez, Elena
A1 Sabio, José M
A1 Callejas, José L
A1 Ramón, Enrique de
A1 Garcia-Portales, Rosa
A1 García-Hernández, Francisco J
A1 Jiménez-Alonso, Juan
A1 González-Escribano, Ma Francisca
A1 Martín, Javier
A1 Koeleman, Bobby P
K1 Adulto
K1 Quimiocina CCL2
K1 Quimiocina CCL5
K1 Quimiocinas
K1 Femenino
K1 Predisposición Genética a la Enfermedad
K1 Genotipo
K1 Humanos
K1 Inflamación
K1 Interleucina-1
K1 Interleucina-8
K1 Interleucinas
K1 Lupus Eritematoso Sistémico
K1 Masculino
K1 Polimorfismo de Nucleótido Simple
AB BACKGROUND. Several lines of evidence suggest that chemokines and cytokines play an important role in the inflammatory development and progression of systemic lupus erythematosus. The aim of this study was to evaluate the relevance of functional genetic variations of RANTES, IL-8, IL-1alpha, and MCP-1 for systemic lupus erythematosus. METHODS. The study was conducted on 500 SLE patients and 481 ethnically matched healthy controls. Genotyping of polymorphisms in the RANTES, IL-8, IL-1alpha, and MCP-1 genes were performed using a real-time polymerase chain reaction (PCR) system with pre-developed TaqMan allelic discrimination assay. RESULTS. No significant differences between SLE patients and healthy controls were observed when comparing genotype, allele or haplotype frequencies of the RANTES, IL-8, IL-1alpha, and MCP-1 polymorphisms. In addition, no evidence for association with clinical sub-features of SLE was found. CONCLUSION. These results suggest that the tested functional variation of RANTES, IL-8, IL-1alpha, and MCP-1 genes do not confer a relevant role in the susceptibility or severity of SLE in the Spanish population.
PB BioMed Central
YR 2006
FD 2006-05-23
LK http://hdl.handle.net/10668/574
UL http://hdl.handle.net/10668/574
LA en
NO Sánchez E, Sabio JM, Callejas JL, Ramón E de, Garcia-Portales E, García-Hernández FJ et al. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. BMC Med Genet. 2006 May 23;7:48.
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 10, 2025