TY - JOUR AU - Gil-Julio, Hernani AU - Perea, Francisco AU - Rodriguez-Nicolas, Antonio AU - Cozar, Jose Manuel AU - González-Ramirez, Amanda Rocío AU - Concha, Angel AU - Garrido, Federico AU - Aptsiauri, Natalia AU - Ruiz-Cabello, Francisco PY - 2021 DO - 10.3390/ijms22147248 UR - http://hdl.handle.net/10668/3478 T2 - International Journal of Molecular Sciences AB - Cancer eradication and clinical outcome of immunotherapy depend on tumor cell immunogenicity, including HLA class I (HLA-I) and PD-L1 expression on malignant cells, and on the characteristics of the tumor microenvironment, such as tumor immune... LA - en PB - MDPI KW - Bladder cancer KW - HLA class I KW - Cancer immune escape KW - TILs KW - T-cell exclusion KW - PD-L1 KW - Cancer associated fibroblasts KW - Neoplasias de la vejiga urinaria KW - Antígeno HLA-A1 KW - Fibroblastos asociados al cáncer KW - Antígeno B7-H1 KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over KW - Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Sexuality::Homosexuality::Homosexuality, Female KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::Histocompatibility Antigens Class I KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunization::Immunotherapy, Active KW - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocytes, Tumor-Infiltrating KW - Medical Subject Headings::Persons::Persons::Men::Nurses, Male KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype::Endophenotypes KW - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocyte Subsets::T-Lymphocyte Subsets::T-Lymphocytes, Cytotoxic KW - Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Tumor Escape KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Urinary Bladder Neoplasms KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Young Adult TI - Tumor Escape Phenotype in Bladder Cancer Is Associated with Loss of HLA Class I Expression, T-Cell Exclusion and Stromal Changes TY - research article ER -