RT Journal Article
T1 Tumor Escape Phenotype in Bladder Cancer Is Associated with Loss of HLA Class I Expression, T-Cell Exclusion and Stromal Changes
A1 Gil-Julio, Hernani
A1 Perea, Francisco
A1 Rodriguez-Nicolas, Antonio
A1 Cozar, Jose Manuel
A1 González-Ramirez, Amanda Rocío
A1 Concha, Angel
A1 Garrido, Federico
A1 Aptsiauri, Natalia
A1 Ruiz-Cabello, Francisco
K1 Bladder cancer
K1 HLA class I
K1 Cancer immune escape
K1 TILs
K1 T-cell exclusion
K1 PD-L1
K1 Cancer associated fibroblasts
K1 Neoplasias de la vejiga urinaria
K1 Antígeno HLA-A1
K1 Fibroblastos asociados al cáncer
K1 Antígeno B7-H1
AB Cancer eradication and clinical outcome of immunotherapy depend on tumor cell immunogenicity, including HLA class I (HLA-I) and PD-L1 expression on malignant cells, and on the characteristics of the tumor microenvironment, such as tumor immune infiltration and stromal reaction. Loss of tumor HLA-I is a common mechanism of immune escape from cytotoxic T lymphocytes and is linked to cancer progression and resistance to immunotherapy with the inhibitors of PD-L1/PD-1 signaling. Here we observed that HLA-I loss in bladder tumors is associated with T cell exclusion and tumor encapsulation with stromal elements rich in FAP-positive cells. In addition, PD-L1 upregulation in HLA-I negative tumors demonstrated a correlation with high tumor grade and worse overall- and cancer-specific survival of the patients. These changes define common immuno-morphological signatures compatible with cancer immune escape and acquired resistance to therapeutic interventions across different types of malignancy. They also may contribute to the search of new targets for cancer treatment, such as FAP-expressing cancer-associated fibroblasts, in refractory bladder tumors.
PB MDPI
YR 2021
FD 2021-07-06
LK http://hdl.handle.net/10668/3478
UL http://hdl.handle.net/10668/3478
LA en
NO Gil-Julio H, Perea F, Rodriguez-Nicolas A, Cozar JM, González-Ramirez AR, Concha A, et al. Tumor Escape Phenotype in Bladder Cancer Is Associated with Loss of HLA Class I Expression, T-Cell Exclusion and Stromal Changes. Int. J. Mol. Sci. 2021, 22, 7248.
DS RISalud
RD Apr 8, 2025