RT Journal Article
T1 Mitral valve prolapse morphofunctional features by cardiovascular magnetic resonance: more than just a valvular disease.
A1 Romero Daza, Angélica
A1 Chokshi, Aalap
A1 Pardo, Patricia
A1 Maneiro, Nicolas
A1 Guijarro Contreras, Ana
A1 Larrañaga-Moreira, Jose M
A1 Ibañez, Borja
A1 Fuster, Valentin
A1 Fernández Friera, Leticia
A1 Solís, Jorge
A1 Sanz, Javier
K1 Cardiovascular magnetic resonance
K1 Mitral regurgitation
K1 Mitral valve prolapse
K1 Myocardial strain
AB Mitral valve (MV) prolapse (MVP) is a primary valvular abnormality. We hypothesized that additionally there are concomitant abnormalities of the left ventricle (LV) and MV apparatus in this entity even in the absence of significant mitral regurgitation (MR). To characterize MV and LV anatomic and functional features in MVP with preserved LV ejection fraction, with and without significant MR, using cardiovascular magnetic resonance (CMR). Consecutive MVP patients (n = 80, mean 52 years, 37% males) with preserved LV ejection fraction, and 44 controls (46 years, 52% males) by CMR were included, as well as 13 additional patients with "borderline" MVP. From cine images we quantified LV volumes, MV and LV anatomic measurements (including angle between diastolic and systolic annular planes, annular displacement, and basal inferolateral hypertrophy) and, using feature tracking, longitudinal and circumferential peak systolic strains. Significant MR was found in 46 (56%) MVP patients. Compared with controls, MVP patients had LV enlargement, basal inferolateral hypertrophy, higher posterior annular excursion, and reduced shortening of the papillary muscles. LV basal strains were significantly increased, particularly in several basal segments. These differences remained significant in patients without significant MR, and many persisted in "borderline" MVP. In patients with MVP and preserved LV ejection fraction there is LV dilatation, basal inferolateral hypertrophy, exaggerated posterior annular displacement and increased basal deformation, even in the absence of significant MR or overt MVP. These findings suggest that MVP is a disease not only of the MV but also of the adjacent myocardium.
YR 2021
FD 2021-10-11
LK https://hdl.handle.net/10668/26904
UL https://hdl.handle.net/10668/26904
LA en
DS RISalud
RD Apr 5, 2025