RT Journal Article
T1 Significance of the Overexpression of Substance P and Its Receptor NK-1R in Head and Neck Carcinogenesis: A Systematic Review and Meta-Analysis
A1 González-Moles, Miguel Ángel
A1 Ramos-García, Pablo
A1 Esteban, Francisco
K1 Substance P
K1 NK-1R
K1 Neurokinin
K1 Tachykinin
K1 Head and neck
K1 Neoplasm
K1 Squamous cell carcinoma
K1 Systematic review
K1 Meta-analysis
K1 Receptores de neuroquinina-1
K1 Taquicininas
K1 Cabeza
K1 Cuello
K1 Neoplasias
K1 Carcinoma de células escamosas
K1 Revisión sistemática
K1 Metaanálisis
K1 Neoplasias de cabeza y cuello
AB The objective of our study has been, through a systematic review and meta-analysis, to increase the scientific evidence on the implications of SP and its receptor NK-1R in head and neck carcinogenesis. We searched studies published before May-2020 without date and publication language restrictions (PubMed, Embase, Web of Science, Scopus). We evaluated the quality of the studies included (QUIPS tool). We performed heterogeneity, sensitivity, small-study effects, and subgroup analyses. A total 16 studies and 1308 cases met inclusion criteria. Qualitative evaluation demonstrated that not all studies were performed with the same scientific rigor, finding the greatest risk of bias in the study confounding and prognostic factors measurement domains. Quantitative evaluation showed a greater SP/NK-1R overexpression in malignant head and neck lesions compared to benign lesions (p = 0.02), and that expression was observed in malignant salivary gland pathology. Likewise, we found a higher overexpression of NK-1R compared to SP (p = 0.02). In conclusion, the results of this systematic review and meta-analysis show evidence that the upregulation of SP and NK-1R are oncogenic events involved in head and neck carcinogenesis, probably acting in the early stages of malignization. In addition, there is evidence of a greater relevance of the upregulation of the NK-1R receptor compared to SP, which highlights the interest in deepening the development of targeted therapies on the receptor. Future studies assessing the relationships between SP/NK-1R among subjects with head and neck tumors could consider the recommendations given in this systematic review and meta-analysis to improve and standardize future research.
PB MDPI
YR 2021
FD 2021-03-17
LK http://hdl.handle.net/10668/4183
UL http://hdl.handle.net/10668/4183
LA en
NO González-Moles MÁ, Ramos-García P, Esteban F. Significance of the Overexpression of Substance P and Its Receptor NK-1R in Head and Neck Carcinogenesis: A Systematic Review and Meta-Analysis. Cancers. 2021 Mar 17;13(6):1349
DS RISalud
RD Apr 10, 2025