RT Journal Article
T1 APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome.
A1 Fallaize, Rosalind
A1 Carvalho-Wells, Andrew L
A1 Tierney, Audrey C
A1 Marin, Carmen
A1 Kieć-Wilk, Beata
A1 Dembińska-Kieć, Aldona
A1 Drevon, Christian A
A1 DeFoort, Catherine
A1 Lopez-Miranda, Jose
A1 Riserus, Ulf
A1 Saris, Wim H
A1 Blaak, Ellen E
A1 Roche, Helen M
A1 Lovegrove, Julie A
K1 Adult
K1 Aged
K1 Apolipoprotein C-II
K1 Apolipoprotein C-III
K1 Apolipoproteins E
K1 Diet
AB Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.
PB Nature Publishing Group
YR 2017
FD 2017-06-05
LK http://hdl.handle.net/10668/11434
UL http://hdl.handle.net/10668/11434
LA en
NO Fallaize R, Carvalho-Wells AL, Tierney AC, Marin C, Kieć-Wilk B, Dembińska-Kieć A, et al. APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome. Sci Rep. 2017 Jul 24;7(1):6274
NO The data used in this analysis was derived from the LIPGENE study, funded by the European Commission Framework Programme 6 (contract no. FOOD-CT-2003-505944) between 2004–2009.
DS RISalud
RD Apr 7, 2025