RT Journal Article
T1 Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study
A1 Jenab, Mazda
A1 Bueno de Mesquita, H Bas
A1 Ferrari, Prieto
A1 van Duijnhoven, Franzel J B
A1 Norat, Teresa
A1 Pischon, Tobias
A1 Jansen, Eugène H J M
A1 Slimani, Nadia
A1 Byrnes, Graham
A1 Rinaldi, 
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Overvad, Kim
A1 Boutron-Ruault, Marie Christine
A1 Clavel-Chapelon, Françoise
A1 Morois, Sophie
A1 Kaaks, Rudolf
A1 Linseisen, Jakob
A1 Boeing, Heiner
A1 Bergmann, Manuela M
A1 Trichopoulou, Antonia
A1 Misirli, Gesthimani
A1 Trichopoulou, Antonia
A1 Berrino, Franco
A1 Vineis, Paolo
A1 Panico, Salvatore
A1 Palli, Domenico
A1 Tumino, Rosario
A1 Martine, M Ros
A1 van Gils, Carla H
A1 Peeters, Petra H
A1 Brustad, Magritt
A1 Lund, Eiliv
A1 Tormo, María José
A1 Ardanaz, Eva
A1 Rodríguez, Laudina
A1 Sanchez-Perez, Maria-Jose
A1 Dorronsoro, Miren
A1 González, Carlos A
A1 Hallmans, Göran
A1 Palmqvist, Richard
A1 Roddam, Andrew
A1 Key, Timothy J
A1 Khaw, Kay Tee
A1 Autier, Philippe
A1 Hainaut, Pierre
A1 Riboli, Elio
K1 Neoplasias colorrectales
K1 Vitamina D
K1 Estudios de Casos y Controles
K1 Europa
AB Objective. To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations.Design Nested case-control study. Setting. The study was conducted within the EPIC study, a cohort of more than 520 000 participants from 10 western European countries. Participants: 1248 cases of incident colorectal cancer, which developed after enrolment into the cohort, were matched to 1248 controls. Main outcome measures. Circulating vitamin D concentration (25-hydroxy-vitamin-D, 25-(OH)D) was measured by enzyme immunoassay. Dietary and lifestyle data were obtained from questionnaires. Incidence rate ratios and 95% confidence intervals for the risk of colorectal cancer by 25-(OH)D concentration and levels of dietary calcium and vitamin D intake were estimated from multivariate conditional logistic regression models, with adjustment for potential dietary and other confounders. Results. 25-(OH)D concentration showed a strong inverse linear dose-response association with risk of colorectal cancer (P for trend <0.001). Compared with a pre-defined mid-level concentration of 25-(OH)D (50.0-75.0 nmol/l), lower levels were associated with higher colorectal cancer risk (<25.0 nmol/l: incidence rate ratio 1.32 (95% confidence interval 0.87 to 2.01); 25.0-49.9 nmol/l: 1.28 (1.05 to 1.56), and higher concentrations associated with lower risk (75.0-99.9 nmol/l: 0.88 (0.68 to 1.13); ≥100.0 nmol/l: 0.77 (0.56 to 1.06)). In analyses by quintile of 25-(OH)D concentration, patients in the highest quintile had a 40% lower risk of colorectal cancer than did those in the lowest quintile (P<0.001). Subgroup analyses showed a strong association for colon but not rectal cancer (P for heterogeneity=0.048). Greater dietary intake of calcium was associated with a lower colorectal cancer risk. Dietary vitamin D was not associated with disease risk. Findings did not vary by sex and were not altered by corrections for season or month of blood donation.Conclusions The results of this large observational study indicate a strong inverse association between levels of pre-diagnostic 25-(OH)D concentration and risk of colorectal cancer in western European populations. Further randomised trials are needed to assess whether increases in circulating 25-(OH)D concentration can effectively decrease the risk of colorectal cancer.
PB BMJ Publishing Group
YR 2010
FD 2010-01-21
LK http://hdl.handle.net/10668/302
UL http://hdl.handle.net/10668/302
LA en
NO Jenab M, Bueno-de-Mesquita HB, Ferrari P, van Duijnhoven FJ, Norat T, Pischon T, et al. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study. BMJ. 2010 Jan 21; 340:b5500
DS RISalud
RD Apr 10, 2025