RT Journal Article
T1 Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort.
A1 Rothwell, Joseph A
A1 Murphy, Neil
A1 Bešević, Jelena
A1 Kliemann, Nathalie
A1 Jenab, Mazda
A1 Ferrari, Pietro
A1 Achaintre, David
A1 Gicquiau, Audrey
A1 Vozar, Béatrice
A1 Scalbert, Augustin
A1 Huybrechts, Inge
A1 Freisling, Heinz
A1 Prehn, Cornelia
A1 Adamski, Jerzy
A1 Cross, Amanda J
A1 Pala, Valeria Maria
A1 Boutron-Ruault, Marie-Christine
A1 Dahm, Christina C
A1 Overvad, Kim
A1 Gram, Inger Torhild
A1 Sandanger, Torkjel M
A1 Skeie, Guri
A1 Jakszyn, Paula
A1 Tsilidis, Kostas K
A1 Aleksandrova, Krasimira
A1 Schulze, Matthias B
A1 Hughes, David J
A1 van Guelpen, Bethany
A1 Bodén, Stina
A1 Sánchez, Maria-José
A1 Schmidt, Julie A
A1 Katzke, Verena
A1 Kühn, Tilman
A1 Colorado-Yohar, Sandra
A1 Tumino, Rosario
A1 Bueno-de-Mesquita, Bas
A1 Vineis, Paolo
A1 Masala, Giovanna
A1 Panico, Salvatore
A1 Eriksen, Anne Kirstine
A1 Tjønneland, Anne
A1 Aune, Dagfinn
A1 Weiderpass, Elisabete
A1 Severi, Gianluca
A1 Chajès, Véronique
A1 Gunter, Marc J
K1 Colorectal Neoplasm
K1 Risk Factors
K1 Targeted Metabolomics
K1 World Cancer Research Fund/American Institute for Cancer Research Recommendations
AB Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants. Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
YR 2020
FD 2020-12-29
LK http://hdl.handle.net/10668/22081
UL http://hdl.handle.net/10668/22081
LA en
DS RISalud
RD Apr 5, 2025