RT Journal Article
T1 In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts.
A1 Abellan, Alicia
A1 Mensink-Bout, Sara M
A1 Garcia-Esteban, Raquel
A1 Beneito, Andrea
A1 Chatzi, Leda
A1 Duarte-Salles, Talita
A1 Fernandez, Mariana F
A1 Garcia-Aymerich, Judith
A1 Granum, Berit
A1 Iñiguez, Carmen
A1 Jaddoe, Vincent W V
A1 Kannan, Kurunthachalam
A1 Lertxundi, Aitana
A1 Lopez-Espinosa, Maria-Jose
A1 Philippat, Claire
A1 Sakhi, Amrit K
A1 Santos, Susana
A1 Siroux, Valérie
A1 Sunyer, Jordi
A1 Trasande, Leonardo
A1 Vafeiadi, Marina
A1 Vela-Soria, Fernando
A1 Yang, Tiffany C
A1 Zabaleta, Carlos
A1 Vrijheid, Martine
A1 Duijts, Liesbeth
A1 Casas, Maribel
K1 Asthma
K1 Bisphenol A
K1 Lung function
K1 Mother-child cohort
K1 Pregnancy
K1 Wheezing
AB In utero exposure to bisphenols, widely used in consumer products, may alter lung development and increase the risk of respiratory morbidity in the offspring. However, evidence is scarce and mostly focused on bisphenol A (BPA) only. To examine the associations of in utero exposure to BPA, bisphenol F (BPF), and bisphenol S (BPS) with asthma, wheeze, and lung function in school-age children, and whether these associations differ by sex. We included 3,007 mother-child pairs from eight European birth cohorts. Bisphenol concentrations were determined in maternal urine samples collected during pregnancy (1999-2010). Between 7 and 11 years of age, current asthma and wheeze were assessed from questionnaires and lung function by spirometry. Wheezing patterns were constructed from questionnaires from early to mid-childhood. We performed adjusted random-effects meta-analysis on individual participant data. Exposure to BPA was prevalent with 90% of maternal samples containing concentrations above detection limits. BPF and BPS were found in 27% and 49% of samples. In utero exposure to BPA was associated with higher odds of current asthma (OR = 1.13, 95% CI = 1.01, 1.27) and wheeze (OR = 1.14, 95% CI = 1.01, 1.30) (p-interaction sex = 0.01) among girls, but not with wheezing patterns nor lung function neither in overall nor among boys. We observed inconsistent associations of BPF and BPS with the respiratory outcomes assessed in overall and sex-stratified analyses. This study suggests that in utero BPA exposure may be associated with higher odds of asthma and wheeze among school-age girls.
YR 2022
FD 2022-03-18
LK http://hdl.handle.net/10668/22203
UL http://hdl.handle.net/10668/22203
LA en
DS RISalud
RD Apr 16, 2025