RT Journal Article
T1 Relevance of BET Family Proteins in SARS-CoV-2 Infection
A1 Lara-Ureña, Nieves
A1 García-Domínguez, Mario
K1 SARS-CoV-2
K1 COVID-19
K1 BET
K1 BET inhibitors
K1 BRD4
K1 BRD2
K1 Virus
K1 Immunity
K1 Inflammation
K1 Betaína-homocisteína S-metiltransferasa
K1 Inmunidad
K1 Inflamación
K1 Infecciones por coronavirus
K1 Proteínas
K1 Factores de transcripción
AB The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world's population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date. This disease is caused by a new type of coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A massive proteomic analysis has revealed that one of the structural proteins of the virus, the E protein, interacts with BRD2 and BRD4 proteins of the Bromodomain and Extra Terminal domain (BET) family of proteins. BETs are essential to cell cycle progression, inflammation and immune response and have also been strongly associated with infection by different types of viruses. The fundamental role BET proteins play in transcription makes them appropriate targets for the propagation strategies of some viruses. Recognition of histone acetylation by BET bromodomains is essential for transcription control. The development of drugs mimicking acetyl groups, and thereby able to displace BET proteins from chromatin, has boosted interest on BETs as attractive targets for therapeutic intervention. The success of these drugs against a variety of diseases in cellular and animal models has been recently enlarged with promising results from SARS-CoV-2 infection studies.
PB MDPI
YR 2021
FD 2021-07-30
LK http://hdl.handle.net/10668/4242
UL http://hdl.handle.net/10668/4242
LA en
NO Lara-Ureña N, García-Domínguez M. Relevance of BET Family Proteins in SARS-CoV-2 Infection. Biomolecules. 2021 Jul 30;11(8):1126
DS RISalud
RD Apr 17, 2025