TY  - JOUR
AU  - Robles-Díaz, Mercedes
AU  - Lucena, M Isabel
AU  - Kaplowitz, Neil
AU  - Stephens, Camilla
AU  - Medina-Cáliz, Inmaculada
AU  - González-Jiménez, Andrés
AU  - Ulzurrun, Eugenia
AU  - González, Ana F
AU  - Fernández, M Carmen
AU  - Romero-Gómez, Manuel
AU  - Jiménez-Pérez, Miguel
AU  - Bruguera, Miguel
AU  - Prieto, Martín
AU  - Bessone, Fernando
AU  - Hernández, Nelia
AU  - Arrese, Marco
AU  - Andrade, Raúl J
PY  - 2014
DO  - 10.1053/j.gastro.2014.03.050
SN  - 0016-5085
UR  - http://hdl.handle.net/10668/1859
T2  - Gastroenterology
AB  - BACKGROUND & AIMSHy's Law, which states that hepatocellular drug-induced liver injury (DILI) with jaundice indicates a serious reaction, is used widely to determine risk for acute liver failure (ALF). We aimed to optimize the definition of Hy's Law...
LA  - en
PB  - WB Saunders
KW  - Idiosyncratic Hepatotoxicity
KW  - Prognostic Risk Factor
KW  - Prediction
KW  - Progression
KW  - Comorbilidad
KW  - Enfermedad hepática inducida por drogas
KW  - Ictericia
KW  - Fallo hepático agudo
KW  - Valor predictivo de las pruebas
KW  - Factores de riesgo
KW  - Sensibilidad y especificidad
KW  - Factores sexuales
KW  - Alanina transaminasa
KW  - Algoritmos
KW  - Bilirrubina
KW  - Marcadores biológicos
KW  - Niños
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged::Aged, 80 and over
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminases::Alanine Transaminase
KW  - Medical Subject Headings::Information Science::Information Science::Computing Methodologies::Algorithms
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Monoester Hydrolases::Alkaline Phosphatase
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminases::Aspartate Aminotransferases
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Pyrroles::Tetrapyrroles::Bile Pigments::Bilirubin
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Child
KW  - Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies
KW  - Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Comorbidity
KW  - Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Drug-Induced Liver Injury
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hyperbilirubinemia::Jaundice
KW  - Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Hepatic Insufficiency::Liver Failure::Liver Failure, Acute
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical
KW  - Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Research Design::Sensitivity and Specificity::Predictive Value of Tests
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
KW  - Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Sensitivity and Specificity
KW  - Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Sex Factors
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Young Adult
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adolescent
TI  - Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury.
TY  - research article
ER  -