TY  - JOUR
AU  - Larramona-Arcas, Raquel
AU  - González-Arias, Candela
AU  - Perea, Gertrudis
AU  - Gutiérrez, Antonia
AU  - Vitorica, Javier
AU  - García-Barrera, Tamara
AU  - Gómez-Ariza, José Luis
AU  - Pascua-Maestro, Raquel
AU  - Ganfornina, María Dolores
AU  - Kara, Eleanna
AU  - Hudry, Eloise
AU  - Martinez-Vicente, Marta
AU  - Vila, Miquel
AU  - Galea, Elena
AU  - Masgrau, Roser
PY  - 2020
DO  - 10.1186/s13024-020-00382-8
UR  - http://hdl.handle.net/10668/3728
T2  - Molecular Neurodegeneration
AB  - Background: The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alzheimer's...
LA  - en
PB  - BioMed Central, Springer Nature
KW  - APOE4
KW  - Astrocytes
KW  - Calcium signaling
KW  - Sex
KW  - Lysosome
KW  - Purinergic receptors
KW  - Lipidome
KW  - Apolipoproteína E4
KW  - Astrocitos
KW  - Señalización del calcio
KW  - Sexo
KW  - Lisosomas
KW  - Receptores purinérgicos
KW  - Lipidómica
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Apolipoproteins::Apolipoproteins E::Apolipoprotein E3
KW  - Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Apolipoproteins::Apolipoproteins E::Apolipoprotein E4
KW  - Medical Subject Headings::Anatomy::Nervous System::Neuroglia::Astrocytes
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Blood Coagulation Factors::Calcium
KW  - Medical Subject Headings::Chemicals and Drugs::Lipids::Membrane Lipids::Sterols::Cholesterol
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus
KW  - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Cytoplasmic Vesicles::Lysosomes
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic
KW  - Medical Subject Headings::Anatomy::Nervous System::Neurons
KW  - Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Sex
TI  - Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice
TY  - research article
ER  -