%0 Journal Article
%A Hidalgo-Moyano, Cristina
%A Rangel-Zuñiga, Oriol Alberto
%A Gomez-Delgado, Francisco
%A Alcala-Diaz, Juan F
%A Rodriguez-Cantalejo, Fernando
%A Yubero-Serrano, Elena M
%A Torres-Peña, Jose D
%A Arenas-de Larriva, Antonio P
%A Camargo, Antonio
%A Perez-Martinez, Pablo
%A Lopez-Miranda, Jose
%A Delgado-Lista, Javier
%T Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study.
%D 2022
%U http://hdl.handle.net/10668/21503
%X We investigated whether long-term consumption of two healthy diets (low-fat (LF) or Mediterranean (Med)) interacts with SIRT1 genotypes to modulate aging-related processes such as leucocyte telomere length (LTL), oxidative stress (OxS) and inflammation in patients with coronary heart disease (CHD). LTL, inflammation, OxS markers (at baseline and after 4 years of follow-up) and SIRT1-Single Nucleotide Polymorphisms (SNPs) (rs7069102 and rs1885472) were determined in patients from the CORDIOPREV study. We analyzed the genotype-marker interactions and the effect of diet on these interactions. Regardless of the diet, we observed LTL maintenance in GG-carriers for the rs7069102, in contrast to carriers of the minor C allele, where it decreased after follow-up (p = 0.001). The GG-carriers showed an increase in reduced/oxidized glutathione (GSH/GSSG) ratio (p = 0.003), lower lipid peroxidation products (LPO) levels (p< 0.001) and a greater decrease in tumor necrosis factor-alpha (TNF-α) levels (p < 0.001) after follow-up. After the LF diet intervention, the GGcarriers showed stabilization in LTL which was significant compared to the C allele subjects (p = 0.037), although the protective effects found for inflammation and OxS markers remained significant after follow-up with the two diets. Patients who are homozygous for the SIRT1-SNP rs7069102 (the most common genotype) may benefit from healthy diets, as suggested by improvements in OxS and inflammation in patients with CHD, which may indicate the slowing-down of the aging process and its related diseases.
%K Aging-related processes
%K Coronary heart disease
%K Genetic variants
%K Healthy diets
%K Role of sirtuins
%~