RT Journal Article
T1 Potential Survival Benefit for Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation after Nivolumab Therapy for Relapse/Refractory Hodgkin Lymphoma: Real-Life Experience in Spain.
A1 Martínez, Carmen
A1 Carpio, Cecilia
A1 Heras, Inmaculada
A1 Ríos-Herranz, Eduardo
A1 Buch, Joan
A1 Gutierrez, Antonio
A1 Romero, Samuel
A1 Zeberio, Izaskun
A1 García-García, Irene
A1 Rodriguez-Izquierdo, Antonia
A1 Alonso, Rosalía
A1 Bargay, Joan
A1 Barrenetxea, Cristina
A1 Domingo-Doménech, Eva
A1 de Haro, Manuel Espeso
A1 Palomera, Luis
A1 García-Sanz, Ramón
A1 Spanish Group of Lymphoma and Bone Marrow Transplantation (GELTAMO), 
K1 Allogeneic transplantation
K1 Hodgkin lymphoma
K1 Nivolumab
K1 Relapsed/refractory lymphoma
AB Clinical trials have shown that nivolumab has remarkable activity against relapsed/refractory classical Hodgkin lymphoma (cHL). However, the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) as consolidation therapy in these patients remains controversial. We performed a retrospective analysis of data from 74 patients treated with nivolumab. The overall response rate was 58% (including 30.6% with complete responses). Treatment-related adverse events were reported in 56.8% of patients (grade ≥3 in 9.4%). The main reasons for nivolumab discontinuation were referral for transplantation (41.7% patients) and disease progression (37.5%). The 2-year overall survival (OS) rate was 52% for the entire series. Ultimately, 39 patients underwent allo-HSCT. The cumulative incidence of grade II-IV acute graft-versus-host disease was 33.3% (grade III-IV in 2 patients). The cumulative incidence of nonrelapse mortality was 13.2%. Among the patients who responded to nivolumab, the 2-year OS and progression-free survival (PFS) were higher in patients who underwent consolidation with allo-HSCT (77.5% versus 42.6% [P = .126] and 73.9% versus 27.2% [P = .025], respectively). Thus, the efficacy and safety of nivolumab were comparable to values reported in previous clinical trials. The percentage of patients who bridged to transplantation was high, indicating a preference for Spanish physicians. These results suggest that consolidation allo-HSCT increases OS and PFS.
YR 2020
FD 2020-02-14
LK http://hdl.handle.net/10668/15119
UL http://hdl.handle.net/10668/15119
LA en
DS RISalud
RD Apr 5, 2025