%0 Journal Article
%A Martínez, Carmen
%A Carpio, Cecilia
%A Heras, Inmaculada
%A Ríos-Herranz, Eduardo
%A Buch, Joan
%A Gutierrez, Antonio
%A Romero, Samuel
%A Zeberio, Izaskun
%A García-García, Irene
%A Rodriguez-Izquierdo, Antonia
%A Alonso, Rosalía
%A Bargay, Joan
%A Barrenetxea, Cristina
%A Domingo-Doménech, Eva
%A de Haro, Manuel Espeso
%A Palomera, Luis
%A García-Sanz, Ramón
%A Spanish Group of Lymphoma and Bone Marrow Transplantation (GELTAMO)
%T Potential Survival Benefit for Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation after Nivolumab Therapy for Relapse/Refractory Hodgkin Lymphoma: Real-Life Experience in Spain.
%D 2020
%U http://hdl.handle.net/10668/15119
%X Clinical trials have shown that nivolumab has remarkable activity against relapsed/refractory classical Hodgkin lymphoma (cHL). However, the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) as consolidation therapy in these patients remains controversial. We performed a retrospective analysis of data from 74 patients treated with nivolumab. The overall response rate was 58% (including 30.6% with complete responses). Treatment-related adverse events were reported in 56.8% of patients (grade ≥3 in 9.4%). The main reasons for nivolumab discontinuation were referral for transplantation (41.7% patients) and disease progression (37.5%). The 2-year overall survival (OS) rate was 52% for the entire series. Ultimately, 39 patients underwent allo-HSCT. The cumulative incidence of grade II-IV acute graft-versus-host disease was 33.3% (grade III-IV in 2 patients). The cumulative incidence of nonrelapse mortality was 13.2%. Among the patients who responded to nivolumab, the 2-year OS and progression-free survival (PFS) were higher in patients who underwent consolidation with allo-HSCT (77.5% versus 42.6% [P = .126] and 73.9% versus 27.2% [P = .025], respectively). Thus, the efficacy and safety of nivolumab were comparable to values reported in previous clinical trials. The percentage of patients who bridged to transplantation was high, indicating a preference for Spanish physicians. These results suggest that consolidation allo-HSCT increases OS and PFS.
%K Allogeneic transplantation
%K Hodgkin lymphoma
%K Nivolumab
%K Relapsed/refractory lymphoma
%~