RT Journal Article
T1 Initial medication non-adherence: prevalence and predictive factors in a cohort of 1.6 million primary care patients.
A1 Aznar-Lou, Ignacio
A1 Fernández, Ana
A1 Gil-Girbau, Montserrat
A1 Fajó-Pascual, Marta
A1 Moreno-Peral, Patricia
A1 Peñarrubia-María, María Teresa
A1 Serrano-Blanco, Antoni
A1 Sánchez-Niubó, Albert
A1 March-Pujol, María Antonia
A1 Jové, Anna Maria
A1 Rubio-Valera, Maria
K1 adherence
K1 big data
K1 clinical pharmacology
K1 pharmacoepidemiology
K1 primary care
AB Adherence to medicines is vital in treating diseases. Initial medication non-adherence (IMNA) - defined as not obtaining a medication the first time it is prescribed - has been poorly explored. Previous studies show IMNA rates between 6 and 28% in primary care (PC). The aims of this study were to determine prevalence and predictive factors of IMNA in the most prescribed and expensive pharmacotherapeutic groups in the Catalan health system. This is a retrospective, register-based cohort study which linked the Catalan PC System (Spain) prescription and invoicing databases. Medication was considered non-initiated when it was not collected from the pharmacy by the end of the month following the one in which it was prescribed. IMNA prevalence was calculated using July 2013-June 2014 prescription data. Predictive factors related to patients, general practitioners and PC centres were identified through multilevel logistic regression analyses. Missing data were attributed using simple imputation. Some 1.6 million patients with 2.9 million prescriptions were included in the study sample. Total IMNA prevalence was 17.6% of prescriptions. The highest IMNA rate was observed in anilides (22.6%) and the lowest in angiotensin-converting-enzyme (ACE) inhibitors (7.4%). Predictors of IMNA are younger age, American nationality, having a pain-related or mental disorder and being treated by a substitute/resident general practitioner in a resident-training centre. The rate of IMNA is high when all medications are taken into account. Attempts to strengthen trust in resident general practitioners and improve motivation to initiate a needed medication in the general young and older immigrant population should be addressed in Catalan PC.
YR 2017
FD 2017-02-24
LK http://hdl.handle.net/10668/10895
UL http://hdl.handle.net/10668/10895
LA en
DS RISalud
RD Apr 11, 2025