RT Journal Article
T1 Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering
A1 Rico-Llanos, Gustavo A.
A1 Borrego-González, Sara
A1 Moncayo-Donoso, Miguelangel
A1 Becerra, José
A1 Visser, Rick
K1 Collagen
K1 Bone tissue engineering
K1 Scaffolds
K1 Growth factors
K1 Peptides
K1 Colágeno
K1 Huesos
K1 Ingeniería de tejidos
K1 Andamios del tejido
K1 Péptidos y proteínas de señalización intercelular
K1 Péptidos
AB Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. This review aims to summarize the current status of collagen type I as a biomaterial for bone tissue engineering, as well as to highlight some of the main efforts that have been made recently towards designing and producing collagen implants to improve bone regeneration.
PB MDPI
YR 2021
FD 2021-02-17
LK http://hdl.handle.net/10668/4139
UL http://hdl.handle.net/10668/4139
LA en
NO Rico-Llanos GA, Borrego-González S, Moncayo-Donoso M, Becerra J, Visser R. Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering. Polymers. 2021 Feb 17;13(4):599
DS RISalud
RD Apr 7, 2025