RT Journal Article
T1 Molecular Radiobiology in Non-Small Cell Lung Cancer: Prognostic and Predictive Response Factors.
A1 Peinado-Serrano, Javier
A1 Carnero, Amancio
K1 NSCLC
K1 biomarkers
K1 prognostic and predictive signature
K1 radiotherapy
AB Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, generating huge economic and social impacts that have not slowed in recent years. Oncological treatment for this neoplasm usually includes surgery, chemotherapy, treatments on molecular targets and ionizing radiation. The prognosis in terms of overall survival (OS) and the different therapeutic responses between patients can be explained, to a large extent, by the existence of widely heterogeneous molecular profiles. The identification of prognostic and predictive gene signatures of response to cancer treatment, could help in making therapeutic decisions in patients affected by NSCLC. Given the published scientific evidence, we believe that the search for prognostic and/or predictive gene signatures of response to radiotherapy treatment can significantly help clinical decision-making. These signatures may condition the fractions, the total dose to be administered and/or the combination of systemic treatments in conjunction with radiation. The ultimate goal is to achieve better clinical results, minimizing the adverse effects associated with current cancer therapies.
SN 2072-6694
YR 2022
FD 2022-04-28
LK http://hdl.handle.net/10668/20889
UL http://hdl.handle.net/10668/20889
LA en
DS RISalud
RD Apr 9, 2025